The Impact of Implant Abutment Angle and Height on Peri-implant Tissue Health: Retrospective Analyses from a Randomized Controlled Clinical Trial.

Purpose: To examine the influence of abutment emergence angle and abutment height on marginal peri-implant bone stability in patients not considered susceptible to peri-implantitis. Furthermore, it was analyzed whether titanium-base (Ti-base) abutments lead to wider abutment emergence angles compared to one-piece abutments.

Materials And Methods: A total of 48 abutments (ie, 24 Ti-base and 24 one-piece abutments in 24 patients) were evaluated at abutment installation, after 1 year, and thereafter on a yearly basis for up to 5 years.

TESTING OF ZIRCONIA FPD FRAMEWORKS FOR FIXED PROSTHESES: MODEL DESIGN AND EVALUATION OF FRACTURE LOAD.

In our previous test model, the abutment teeth and the model base were printed with resin and bonded with a polyether material. Some abutment teeth were fractured during the mechanical load test. Therefore, the aim was to develop and evaluate a new model under mechanical loading until fracture with zirconia FPD frameworks.

Customized Titanium Mesh for Guided Bone Regeneration in the Posterior Mandible in a Patient Previously Treated with Bisphosphonates.

We describe the restorative treatment of an 86-year-old female patient who was referred to our specialist prosthodontics clinic. Due to secondary osteoporosis, she underwent oral antiresorptive therapy with ibandronic acid for 10 years. Although she was classified as a patient at increased risk of drug-induced osteonecrosis of the jaw, she eventually signed a consent form for fixed implant-supported prosthetic rehabilitation in her 4th sextant.

Long-term effects of titanium-base abutments on peri-implant health: A 5-year randomised controlled trial.

Purpose: Titanium bases are used frequently in daily practice for bonding to CAD/CAM abutments or crowns. Due to intimate contact between the adhesive gap of the titanium-base abutment and the peri-implant bone, the physical and chemical characteristics of the bonding material, or the gap itself, may affect peri-implant inflammatory reactions. The present study therefore aimed to examine the long-term effects of individualised abutments bonded to titanium bases on peri-implant health.

Inflammatory effects of individualized abutments bonded onto titanium base on peri-implant tissue health: A randomized controlled clinical trial.

Background: In implant prosthodontics, computer-assisted design and computer-assisted manufacturing (CAD/CAM) zirconia abutments bonded onto titanium bases are frequently used in prosthetic dentistry. Unpolymerized monomer of the bonding material or the adhesive gap itself may have a negative effect on peri-implant tissue health. However, evidence addressing this problem is not available.

Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature.

Natural killer (NK) cells, as members of the innate immune system, and natural killer T (NKT) cells, bridging innate and adaptive immunity, play a prominent role in chronic inflammatory diseases and cancerogenesis, yet have scarcely been examined in oral diseases. Therefore, systematic research on the latest literature focusing on NK/NKT cell-mediated mechanisms in periodontal disease, including the time period 1988-2020, was carried out in MEDLINE (PubMed) using a predetermined search strategy, with a final selection of 25 studies. The results showed that NK cells tend to have rather proinflammatory influences via cytokine production, cytotoxic effects, dendritic-cell-crosstalk, and autoimmune reactions, while contrarily, NKT cell-mediated mechanisms were proinflammatory and immunoregulatory, ranging from protective effects via B-cell-regulation, specific antibody production, and the suppression of autoimmunity to destructive effects via cytokine production, dendritic-cell-crosstalk, and T-/B-cell interactions.

Application of a standard autoclaving protocol does not harm structural integrity of two-piece zirconia abutments under detachment force testing.

Objective: Aim was to assess the influence of a standard autoclaving protocol on the retention of zirconia abutments glued on titanium bases in two-piece implant abutments.

Materials And Methods: Twenty-four CAD/CAM-generated zirconia abutments were adhesively cemented on prefabricated titanium bases. Before mechanical and thermal aging, the specimens were divided into two groups.

Influence of Connector Diameter on Fracture Load of CAD/CAM-Processed Monolithic Lithium Disilicate Fixed Partial Dentures.

Purpose: To investigate the influence of connector diameter on the mechanical load to fracture in monolithic three-unit lithium disilicate fixed partial dentures (FPDs).

Materials And Methods: A total of 24 FPDs were designed and manufactured using computer-aided design/computer-assisted manufacturing (CAD/CAM) with connector diameters of 16 mm2, 12 mm, or 9 mm (Groups A, B, and C, respectively; n = 8 for each group). After thermal and mechanical aging, the FPDs were subjected to mechanical load-to-fracture assessment.

Correction to: human periodontal ligament fibroblasts stimulated by nanocrystalline hydroxyapatite paste or enamel matrix derivative. An in vitro assessment of PDL attachment, migration, and proliferation.

In the original published version of this article, the middle name for author Mirko H. H. Schmidt is missing.

Annual failure rates and marginal bone-level changes of immediate compared to conventional loading of dental implants. A systematic review of the literature and meta-analysis.

Background: Immediate loading of dental implants appears to be a successful option. Questions still remain whether annual failure rates (AFRs) as well as annual marginal bone-level changes are comparable with conventionally loaded implants.

Hypothesis: Immediately loaded implants (≤24 h after implantation) do not show different annual survival rates or peri-implant bone-level changes as compared to conventionally loaded implants (≥3 months after implantation).

Tissue-engineered mandibular bone reconstruction for continuity defects: a systematic approach to the literature.

Background: Despite significant surgical advances over the last decades, segmental mandibular bone repair remains a challenge. In light of this, tissue engineering might offer a next step in the evolution of mandibular reconstruction.

Purpose: The purpose of the present report was to (1) systematically review preclinical in vivo as well as clinical literature regarding bone tissue engineering for mandibular continuity defects, and (2) to analyze their effectiveness.

Long-term survival of calcium phosphate-coated dental implants: a meta-analytical approach to the clinical literature.

Background: Calcium phosphate ceramic coatings have the potential to compensate for challenging bone conditions such as delayed or impaired bone healing and low bone quantity or density. Thus, the increasing universal prevalence of subjects with such challenging bone conditions might be paralleled by an enhanced global use of calcium phosphate ceramic-coated dental implants. However, it is speculated that the long-term clinical survival of calcium phosphate-coated dental implants might be adversely affected by coating delamination.

Bone regeneration related to calcium phosphate-coated implants in osteoporotic animal models: a meta-analysis.

Background: Osteoporosis is a frequent human metabolic bone disorder. Prospectively, global ageing of populations will lead to a major increase of subjects being diagnosed with osteoporosis and in need for dental rehabilitation. However, as local osteoporosis of the jaws affects bone quantity and quality of edentulous regions, osseointegration of dental implants might be hampered.

Effect of implant surface properties on peri-implant bone healing: implant stability and microcomputed tomographic analysis.

Purpose: The present study aimed to evaluate and compare two types of implants: grit-blasted and acidetched implants (SLActive) and nanometer-scale hydroxyapatite-modified implants (NanoTite).

Materials And Methods: Twenty-two SLActive and 22 NanoTite implants were inserted into the mandibles of 11 beagle dogs. The animals were divided into three groups according to healing time (group A, 2 weeks; group B, 4 weeks; group C, 8 weeks).

Human periodontal ligament fibroblasts stimulated by nanocrystalline hydroxyapatite paste or enamel matrix derivative. An in vitro assessment of PDL attachment, migration, and proliferation.

We determined the effects of soluble or coated nanocrystalline hydroxyapatite paste (nano-HA) and enamel matrix derivative (EMD) on proliferation, adhesion, and migration of periodontal ligament fibroblasts (PDLs). Cultured PDLs were stimulated with nano-HA paste or EMD in a soluble form or were coated to the surface of cell culture dishes. Proliferation of PDLs on coated nano-HA and EMD was quantified by various methods including bromodeoxyuridine (BrdU) incorporation and Western blot.

Effect of implant surface properties on peri-implant bone healing: a histological and histomorphometric study in dogs.

Aim: The present study aimed to evaluate and compare two types of implants, i.e. grit-blasted and acid-etched implants (SLActive(®)) with nano-meter-scale hydroxyapatite surface-modified implants (NanoTite™).

Influence of different biomaterials on the viability of Aggregatibacter actinomycetemcomitans.

Objectives: The aim of the present in vitro study was to evaluate the effects of different biomaterials used for regenerative periodontal surgery on the growth of the periodontopathogen Aggregatibacter actinomycetemcomitans.

Methods: Three commercially available biomaterials of synthetic origin (hydroxyapatite/beta-tricalcium phosphate, nanostructured hydroxyapatite paste, oily calcium hydroxide suspension), a bovine-derived xenograft as well as an enamel matrix derivative (EMD) were added in different concentrations to calibrated suspensions of A. actinomycetemcomitans ATCC 43718/33384 (serotype b/c).

Study of the osseointegration of dental implants placed with an adapted surgical technique.

Objective: To study the osseointegration of dental implants placed with a modified surgical technique in Beagle dogs and to compare it with the conventional method.

Materials And Methods: Dental implants were placed bilaterally in the mandible of Beagle dogs using the press-fit as well as undersized implant bed preparation technique. Micro computer tomography (micro-CT) and histometric methods were used to analyze the bone implant contact and bone volume (BV) around the implants.

Carbon nanotubes in animal models: a systematic review on toxic potential.

Amongst the engineered nanomaterials, especially carbon nanotubes (CNTs) have received considerable attention for application in tissue engineering scaffolds. CNTs are considered promising on behalf of their physicochemical properties, yet such nanomaterials also have been associated with potentially hazardous effects on human health. To gain insight into the toxicity aspects of CNTs in vivo, the present study presents a systematic review of literature.

Effects of implant surface coatings and composition on bone integration: a systematic review.

Objective: The aim of the present review was to evaluate the bone integration efficacy of recently developed and marketed oral implants as well as experimental surface alterations.

Materials And Methods: A PubMed search was performed for animal studies, human reports and studies presenting bone-to-implant contact percentage or data regarding mechanical testing.

Results: For recently developed and marketed oral implants, 29 publications and for experimental surface alterations 51 publications fulfilled the inclusion criteria for this review.

The effect of enamel matrix derivative (Emdogain) on bone formation: a systematic review.

This systematic review focused on the question, if and to what extent enamel matrix derivative (Emdogain) [EMD]) promotes the regeneration of bone. The influence of combinations with other biomaterials was additionally evaluated. Twenty histomorphometric studies were included in this systematic review.

Toward guided tissue and bone regeneration: morphology, attachment, proliferation, and migration of cells cultured on collagen barrier membranes. A systematic review.

Collagen barrier membranes are frequently used in both guided tissue regeneration (GTR) and guided bone regeneration (GBR). Collagen used for these devices is available from different species and is often processed to alter the properties of the final product. This is necessary because unprocessed collagen is rapidly resorbed in vivo and demands for barrier membranes are different in GTR and GBR.

[The use of Emdogain in periodontal and osseous regeneration].

The goal of regenerative periodontal therapy is the reconstitution of the lost periodontal structures (i. e. the new formation of root cementum, periodontal ligament and alveolar bone).

Transtympanic corticoid therapy for acute profound hearing loss.

The prognosis of idiopathic sudden hearing loss depends on its severity; acute complete deafness, for example, has a particularly bad prognosis. The treatment of acute deafness is based on a systemic application of corticosteroids. Corticoid concentrations in the cochlea are higher after transtympanic application in comparison to systemic application.

Functional gain of already implanted hearing devices in patients with sensorineural hearing loss of varied origin and extent: Berlin experience.

Objective: The evaluation process of patients with sensorineural hearing loss (SNHL) as candidates for an implantable hearing device is a complex matter. Different criteria have to be considered, such as audiologic, psychological, and socioeconomic issues, presently fitted hearing aids, and the patient's satisfaction with hearing aids. The objective of this study was to describe the evaluation process to select candidates for implantation of the Vibrant Soundbridge system (Symphonix Devices, Inc.