Mesenchymal stromal cell implantation for stimulation of long bone healing aggravates Staphylococcus aureus induced osteomyelitis.

Large bone defects requiring long-term osteosynthetic stabilization or repeated surgeries show a considerable rate of infection. Mesenchymal stromal cells (MSCs) have been successfully used to enhance bone regeneration, but their powerful immunomodulatory effects may impose an enhanced risk for osteomyelitis development. In order to unravel whether implantation of MSCs aggravates a simultaneous bone infection, a hydrogel-supported osteomyelitis ostectomy model was developed in which rats received a femoral bone defect with rigid plate-fixation.

A vibrational technique for diagnosing loosened total hip endoprostheses: an experimental sawbone study.

Aseptic loosening of hip implants is a severe orthopaedic problem and a valid diagnosis is often difficult. A potential method to determine loosening of the prosthesis is a swing analysis of the bone-implant interface using a vibrational technique. In this study, hip models were constructed to assess the vibration behaviour of the stem and cup components.

In vivo failure analysis of intramedullary cement restrictors in 100 hip arthroplasties.

Background: We occasionally noticed excessive distal plug position in our clinical routine of cemented hip arthroplasties. We therefore performed an analysis of risk factors for migration of a biodegradable intramedullary gelatine plug.

Patients And Methods: The performance of a cement restrictor was studied in 100 consecutive cemented total hip arthroplasties implanted with third-generation cementing techniques.

Effects of vascular perfusion on coagulation size in radiofrequency ablation of ex vivo perfused bovine livers.

Objectives: A standardized perfused ex vivo bovine liver model was used to evaluate the effect of organ perfusion on coagulation size and energy deposition during radiofrequency ablation (RFA) procedures.

Materials And Methods: Bovine livers were perfused in a tank after rinsing the prepared liver vessels with anticoagulants. Tyrode's solution, oxygenated and heated to 36.