Publications by authors named "Rudi Ammann"
Clinical and genetic characteristics of hereditary pancreatitis in Europe.
Clin Gastroenterol Hepatol
March 2004
Article Synopsis
- Hereditary pancreatitis, primarily caused by mutations in the PRSS1 gene, is studied for its phenotype-genotype correlations across families in Europe.
- In a study of 112 families, various mutations were identified, with significant differences in the age of symptom onset and the cumulative risk of exocrine and endocrine failure based on specific mutations.
- The research concludes that hereditary pancreatitis leads to earlier symptoms and higher risks of pancreatic failure and cancer after age 50, regardless of genetics.