[A retrospective analysis of using zonisamide and retention in monotherapy among patients with epilepsy in routine clinical practice].

Introduction: Zonisamide is one of the first antiepileptic drugs of new generation with a wide spectrum of action. It is successfully used in treatment of epilepsy for 30 years. The study aims at analyzing the results of the multicenter Russian trial on the efficacy and tolerability of zonisamide and retention in monotherapy.

[Brivaracetam in the treatment of patients with epilepsy].

The newest antiepileptic drug (AED) brivaracetam (Briviac, UCB Pharma) (BRV) was approved in the Russian Federation in 2017 as an adjuvant therapy for the treatment of partial seizures with/without secondary generalization in adults and adolescents over 16 years old with epilepsy. This review contains the data of BRV preclinical studies, pharmacokinetic profile and the results of comparative study of BRV and LEV. The results of main studies of efficacy and tolerability with pooled analysis as well as data from meta-analysis are presented.

[Lacosamide (vimpat). Prospects for clinical application].

This article presents the review of the most significant studies of the efficacy and tolerability of lacosamide (LCM) in treatment of patients with focal epilepsy. The review includes the results of the main studies which preceded the official approval of LCM use in mono- and polytherapy. Results on the efficacy of LCM in long-term use and treatment retention in clinical practice, most effective LCM combinations, tolerability, an influence on cognitive and mental functions, advantages in treatment of elderly patients are presented.

[Diabetic asymmetric proximal neuropathy].

Aim: To study the prevalence, clinical features and treatment of diabetic asymmetric proximal neuropathy (DAPN).

Material And Methods: Four hundred and forty-five patients with diabetes mellitus (DM), 257 women and 188 men, mean age 47.6±0.

[New possibilities of monotherapy of symptomatic and cryptogenic partial epilepsy].

This literature review is devoted to the use of the antiepileptic drug zonisamide in the initial monotherapy of symptomatic and cryptogenic partial epilepsy. The review is based on the results of the trials, level of evidence A, that demonstrate the efficacy and tolerability of zonisamide comparable to those of carbamazepine. The possible advantages of zonisamide in different clinical situations and characteristics of its use related to molecule structure, pharmacokinetics, mechanisms of drug action are discussed.

[Changes in gingival blood circulation in patients with provisional fixed acrylic dentures].

The adhesion of oral microorganisms to the surface of teeth and dental restorative materials is often the starting point in the developments of caries and periodontal disease. Formation of biofilm on the surface provisional acrylic bridge is especially quickly and can potentially generate decay or periodontal disease on the teeth. Occlusion trauma and occlusion disorders effects on increasing of injure regional periodontal tissues.

[Possibilities of using intravenous forms of antiepileptic drugs in epileptic seizures].

The literature data on using intravenous forms of AEDs that expand treatment possibilities for patients with epilepsy are presented. AEDs can be used in different situations, when patients are not able to take AEDs in per os. These situations can include seizure emergencies (recurrent seizures, clusters, status epilepticus), caused by disease decompensation; acute symptomatic seizures; perioperative preparation in the case of surgery; dysphagia; gastrointestinal problems; psychiatric disorders, and others.

Synthesis, local anaesthetic and antiarrhythmic activities of N-alkyl derivatives of proline anilides.

We describe here the design, synthesis and evaluation of in vivo local anaesthetic and antiarrhythmic activities of a series of N-alkylproline anilides. Most of the compounds demonstrated surface anaesthetic activity higher than that of lidocaine, ropivacaine and bupivacaine. We established that the local anaesthetic activity was sensitive to structural variations in the substitution pattern at the aromatic ring and the type of alkyl group at the proline nitrogen atom.

[Pharmacotherapy of epilepsy: the use of topiramate in initial and additional treatment].

Topiramate (topamax) is an antiepileptic drug of the new generation that was first registered and introduced in clinical practice in 1995. Due to its effective clinical properties, the drug is used widely all over the world including Russia where it has been using since 1999. Topamax is a principally new antiepileptic drug (AED) with the unique mechanism of action, favorable pharmacokinetics, high efficacy and safety.

[The quality control of nutrient medium in laboratory bacteriologic diagnostics of diphtheria].

The article deals with the results of studying the growth characteristics of nine nutrient mediums for primary plating of pathologic material. It is demonstrated that for successful and proper functioning of bacteriologic laboratory providing bacterial analysis for diphtheria the permanent quality control is needed to monitor the nutrient mediums for primary plating. The quality control is applied to evaluate the growth characteristics on such criteria as germination of isolated culture, intensity of its growth in 24 and 48 hours, optimal size of colonies characterized by their cultural characteristics, inhibiting activity concerning concurrent microflora.

[Characteristics of Bordetelia pertussis strains isolated from pertussis patients in Moscow by using multilocus sequencing].

Aim: Genotyping of B. pertussis strains isolated from pertussis patients in Moscow.

Materials And Methods: 53 strains of B.

[Epilepsy in elderly].

Seventy-two elderly patients with a possible diagnosis of epilepsy were studied. A study included the evaluation of anamnesis, clinical and neurological examination, EEG and/or video-EEG-monitoring, MRI of the brain. The follow-up period was 1-5 years (on average 3 years).

[Topiramate as an example of using generics in the treatment of epilepsy].

Causes of losing the pharmacological remission with duration of more than one year have been analyzed in 220 patients with epilepsy. The most often cause of losing control of seizures was switching from brand antiepileptic drugs to generic analogue (60,4% of patients) with 28,2% of them being switched to topiramate generics. The results of switching of 160 patients from the brand form of topiramate (topamax) to its generics were compared to those in the control group of 52 patients who continued to receive the original form.

[Levetiracetam (keppra) in the treatment of different epileptic syndromes in adults].

One hundred and thirty-eight patients (76 women and 62 men, aged from 16 to 65 years) with symptomatic partial epilepsy (n=128) and idiopathic generalized epilepsy (n=10) have been studied. All patients received keppra on regiments of monotherapy (n=30) and polytherapy (n=108). The study included evaluation of anamnesis, clinical and neurophysiological examination, routine EEG and/or video-EEG-monitoring, MRI of the brain, assessment of effectiveness, tolerability and quality of life (QUALIE-31, version 1).

[Initial precipitating injury and symptomatic focal epilepsies].

A study included 793 epileptic patients. Symptomatic epilepsy caused by initial precipitating injury (IPI) was diagnosed in 151 cases. Evaluation of anamnesis, clinical and neurological examination, routine EEG and/or video-EEG-monitoring and MRI of the brain were carried out.

[Occipital lobe epilepsy in adults].

Five hundreds and thirty-six patients, aged from 19 to 50 years, have been studied. Occipital lobe epilepsy (OLE) have been diagnosed in 22 (4,1%) of cases. The study included evaluation of anamnesis, clinical and neurological examination, routine EEG and/or video-EEG monitoring and MRI of the brain.

[Non-terminal remission in epileptic patients].

Seven hundreds and fifty-eight patients with epilepsy have been studied. Non-terminal remission (temporal stop of seizures with the following relapse) has been diagnosed in 18,3% of cases. An aim of the study was to investigate clinical characteristics and prognosis in patients with such type of remission.

[Focal epilepsies in adults: prognosis of treatment effectiveness].

One hundred and seventy-five patients (73 men and 102 women, aged 16-76 years) with symptomatic and probable symptomatic epilepsies, were studied. The duration of disease was from few months to 38 years. The study included evaluation of anamnesis, clinical and neurological examination, routine EEG and/or video-EEG-monitoring, X-ray CT and/or MRI of the brain.

[Impact of the current antiepileptic drugs on quality of life of epileptic patients].

The purpose of the study was the comparative evaluation of antiepileptic drugs (AED) impact on quality of life (QOL). One hundred and ninety-two patients with symptomatic and probably symptomatic focal epilepsies (mean age 30, 6 +/- 1.05) were investigated.

[Clinical and economical effectiveness of the treatment of focal epilepsies].

One hundred and seventy-three patients with symptomatic and probable symptomatic epilepsies, mean age 31.2 years, were studied. The study included evaluation of anamnesis, clinical and neurological examination, routine EEG and/or video-EEG-monitoring, X-ray CT and/or MRI of the brain.

[Problem of adaptation and characteristics of the etiology of diseases in the Far North].

Extensive data covering 2086 examinees served for analysis of peripheral vascular, locomotion, neurologic disorders developing at various stages of adaptation process in workers engaged into mining in the North. Unfavorable general and local cooling resulted in overstrain of thermoregulation mechanisms, caused lower performance, difficulties in adequate occupational functioning, early formation of diseases. Association of cooling and intensive vibration with significant physical load induced neurovascular and neurodystrophic changes being a result of both local microcirculation disturbances and disordered regulation of peripheral vascular tone, higher excitability of vasoconstrictors stimulated by central mechanisms.

Flavin-dependent alcohol oxidase from the yeast Pichia pinus. Spatial localization of the coenzyme FAD in the protein structure: hot-tritium bombardment and ESR experiments.

The spatial localization of the coenzyme FAD in the quaternary structure of the alcohol oxidase from the yeast Pichia pinus was studied by tritium planigraphy and ESR methods. In the present paper we measured the specific radioactivity of FAD labelled as a part of the alcohol oxidase complex. The specific-radioactivity ratio for two FAD portions (FMN and AMP) was calculated.

Use of conjugates of bovine serum albumin with poly(alkylene oxide)s for solubilization of riboflavin ester.

Solubilization of 2',3',4',5'-tetrabenzoyl-5-acetyl-1,5-dihydroriboflavin (benzaflavin) by conjugates of BSA with poly(alkylene oxide)s [poly(ethylene glycol) and block co-polymers of ethylene oxide and propylene oxide (pluronics)] was investigated. Conjugates of BSA with pluronics were shown to have more solubilizing efficiency towards benzaflavin than BSA itself. Solubilized forms of benzaflavin are able to inhibit NADPH-dependent peroxidation of lipids in rat liver microsomes.