Publications by authors named "Ruda Wei"
Article Synopsis
- - The study investigates CCNF, a protein involved in transferring ubiquitin to regulate tumor cell transitions, and its overexpression across various cancer types, indicating it could serve as a pancancer biomarker and immunotherapy target.
- - Analysis of TCGA datasets revealed that CCNF mRNA and protein levels are elevated in multiple cancers compared to normal tissues, with overexpression linked to poorer overall and recurrence-free survival, and possibly caused by hypomethylation of the CCNF gene.
- - CCNF expression varies significantly by patient sex and race, and its overexpression may hinder immune cell infiltration in tumors; moreover, miR-98-5p is identified as a negative regulator of CCNF expression.
Background: Idiopathic pulmonary arterial hypertension (IPAH) is characterized by medial hypertrophy due to pulmonary artery smooth muscle cell (PASMC) hyperplasia. In the present study, we conducted bioinformatic analyses and cellular experiments to assess the involvement of the interleukin-13 (IL-13) in IPAH.
Methods: The differentially expressed genes (DEGs) in IPAH and DEGs in IPAH caused by IL-13 treatment were screened using the GEO database.
Background: Tuberculosis (TB) is an infectious disease that poses a significant health threat and is one of the leading causes of death worldwide. Diabetes mellitus (DM) has high morbidity and mortality rates. Previous studies have reported that comorbidities can influence one another and aggravate immune disorders.
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