Publications by authors named "Ruchit Rana"
Background: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy, characterized by delayed onset of repetitive vomiting occurring 1 to 4 h following ingestion of a food allergen. Managing FPIES requires strict avoidance of the food trigger. The concern with FPIES is determining the risk of another FPIES food trigger reaction due to potential coassociations with other foods or food groups.
View Article and Find Full Text PDFA Second Slice of FPIES: A Single-Center Reappraisal of Pediatric FPIES.
J Allergy Clin Immunol Pract
August 2024
Background: Food protein-induced enterocolitis syndrome (FPIES) is being increasingly recognized as a non-IgE-mediated food allergy; however, it remains unclear if and how the presentation, diagnosis, and management of this disease has changed in recent years.
Objective: To reappraise the FPIES cohort at a large US pediatric tertiary referral center.
Methods: We performed a retrospective chart review of pediatric patients with FPIES (International Classification of Diseases, Tenth Revision code K52.
Mutations in the N-terminal WD40 domain of coatomer protein complex subunit α (COPA) cause a type I interferonopathy, typically characterized by alveolar hemorrhage, arthritis, and nephritis. We described 3 heterozygous mutations in the C-terminal domain (CTD) of COPA (p.C1013S, p.
View Article and Find Full Text PDFArticle Synopsis
- - Food allergies are increasing, and while avoidance and acute reaction management are traditional treatments, complete avoidance isn't always possible; Food Allergen Immunotherapy (FAIT) is a new treatment aiming to desensitize patients to food allergens.
- - Recent studies show that various FAIT methods, particularly for peanuts, milk, and eggs, have successfully desensitized some patients, but there's limited long-term data on sustained unresponsiveness (SU).
- - FAIT could alleviate the burden of food allergies, particularly in children, but more research is needed to compare the effectiveness of different immunotherapy methods across various age groups.
Objectives: Formal nighttime education is becoming increasingly necessary as more internal medicine (IM) residency programs adopt night-float rotations (NFRs); however, the efficacy of an NFR curriculum throughout an academic year and which topics in an NFR curriculum increase trainee confidence are unknown. We implemented a 12-module, self-paced NFR curriculum for 76 postgraduate year-1 residents at an academic IM residency program. We evaluated the impact of this curriculum on postgraduate year-1 residents' clinical confidence, as well as longitudinal efficacy of the curriculum.
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