Publications by authors named "Ruchi Ojha"
The intracellular human pathogen Shigella invades the colonic epithelium to cause disease. Prior to invasion, this bacterium navigates through different environments within the human body, including the stomach and the small intestine. To adapt to changing environments, Shigella uses the bacterial second messenger cyclic di-GMP (c di-GMP) signaling system, synthesized by diguanylate cyclases (DGCs) encoding GGDEF domains.
View Article and Find Full Text PDFThe intracellular human pathogen invades the colonic epithelium to cause disease. Prior to invasion, this bacterium navigates through different environments within the human body, including the stomach and the small intestine. To adapt to changing environments, uses the bacterial second messenger c-di-GMP signaling system, synthesized by diguanylate cyclases (DGCs) encoding GGDEF domains.
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- Next-generation sequencing has greatly increased data on enzyme sequences, many of which are unstudied but could enhance understanding of enzyme evolution.
- Integrating teaching and research in college can help characterize numerous enzymes, particularly focusing on SABATH methyltransferases that convert salicylic acid into methyl salicylate.
- The study shows that there's a strong conservation of substrate preference in SA methyltransferases, with specific genetic features influencing their function, but many sequences still await analysis, indicating vast potential for future research.
Shigella flexneri is an intracellular human pathogen that invades colonic cells and causes bloody diarrhea. S. flexneri evolved from commensal Escherichia coli, and genome comparisons reveal that S.
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