Publications by authors named "Ruchi Jaiswal"
Article Synopsis
- The endothelium is a key target for various metabolic stressors and drugs, leading to significant changes in the proteins expressed by endothelial cells (ECs).
- Researchers cultured human aortic ECs from healthy and type 2 diabetic donors and treated them with a combination of trans-resveratrol and hesperetin (tRES+HESP), analyzing the resulting protein profiles.
- A total of 3666 proteins were identified, with notable differences found between diabetic and healthy ECs, and tRES+HESP treatment resulted in reversing some of these differences, particularly affecting proteins involved in angiogenesis, such as TGFβ receptors.
Skeletal muscle insulin resistance is a major contributor to type-2 diabetes (T2D). Pioglitazone is a potent insulin sensitizer of peripheral tissues by targeting peroxisome proliferator-activated receptor gamma. Pioglitazone has been reported to protect skeletal muscle cells from lipotoxicity by promoting fatty acid mobilization and insulin signaling.
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