Targeting liver cancer via ASGP receptor using 5-FU-loaded surface-modified PLGA nanoparticles.

Context: Liver cancer is widespread liver malignancy in the world, for an estimated one million deaths annually.

Objective: In present work, lactobionic acid conjugated PLGA nanoparticles (LDNPs) bearing 5-Fluorouracil (5-FU) were developed for targeted delivery to hepatocellular carcinoma.

Materials And Methods: Lactobionic acid conjugated PLGA was used to prepare LDNPs using modified emulsion diffusion method.