Structuring Formative Feedback in an Online Graphics Design Course in BME.

Unlabelled: With a motivation to immerse students in engineering design, graphics communication, and computer aided design (CAD) skills early-on in the biomedical engineering curriculum, we launched a new 2-unit laboratory course on "Graphics Design in BME" in the Spring 2020 quarter for UC Davis sophomores. Due to the COVID-19 pandemic, the course met with the significant challenge of conversion to an online mode of teaching, instead of planned face-to-face instruction. Providing formative feedback was thought to be an important step to help students succeed in their final CAD project of the course.

Gender Differences During Toddlerhood in Autism Spectrum Disorder: A Prospective Community-Based Longitudinal Follow-Up Study.

Relatively few studies have examined gender differences in infants and toddlers, and most focus on clinically referred samples or high-risk infant cohorts. The current study aimed to examine gender differences in early autism manifestations and cognitive development in a community-ascertained sample. In total, 46 males and 21 females with ASD were seen at approximately 24 and 48 months of age.

ROS-responsive microspheres for on demand antioxidant therapy in a model of diabetic peripheral arterial disease.

A new microparticle-based delivery system was synthesized from reactive oxygen species (ROS)-responsive poly(propylene sulfide) (PPS) and tested for "on demand" antioxidant therapy. PPS is hydrophobic but undergoes a phase change to become hydrophilic upon oxidation and thus provides a useful platform for ROS-demanded drug release. This platform was tested for delivery of the promising anti-inflammatory and antioxidant therapeutic molecule curcumin, which is currently limited in use in its free form due to poor pharmacokinetic properties.

Molecular imaging of experimental abdominal aortic aneurysms.

Current laboratory research in the field of abdominal aortic aneurysm (AAA) disease often utilizes small animal experimental models induced by genetic manipulation or chemical application. This has led to the use and development of multiple high-resolution molecular imaging modalities capable of tracking disease progression, quantifying the role of inflammation, and evaluating the effects of potential therapeutics. In vivo imaging reduces the number of research animals used, provides molecular and cellular information, and allows for longitudinal studies, a necessity when tracking vessel expansion in a single animal.

Dual pH- and temperature-responsive microparticles for protein delivery to ischemic tissues.

Injectable "smart" microspheres that are sensitive to both temperature and pH have been fabricated and tested for controlled delivery of therapeutic proteins to ischemic skeletal muscle. A library of copolymers composed of N-isopropyl acrylamide (NIPAAm), propyl acrylic acid (PAA), and butyl acrylate (BA) was used to fabricate microspheres using a double emulsion method, and an optimal formulation made from copolymers composed of 57 mol.% NIPAAm, 18 mol.

GIS based water quality indexing of Malad creek, Mumbai (India): an impact of sewage discharges.

Malad creek is one of the most heavily polluted water bodies in Mumbai, India. Presently, creek receives wastewater and sewage from open drains and nallahs as well as partially treated wastewater from treatment facilities. The objective of the present study was to assess and classify the water quality zones spatially and temporally based on physico-chemical and bacteriological analysis.