PFOA, PFOS and PFHxS toxicokinetic considerations for the development of an in vivo approach for assessing PFAS relative bioavailability in soil.

A Sprague-Dawley rat model was utilized to elucidate perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) toxicokinetics with a goal of developing an in vivo approach for quantifying PFAS relative bioavailability in impacted soil. Following single dose administration (gavage) of ∼ 0.2-2000 µg kg BW of PFOA, PFOS or PFHxS, differences in PFAS blood, organ and excreta concentrations were observed over 120 h although linear dose responses were determined for area under the blood plasma time curves (AUC; PFOA, PFHxS), liver accumulation (LA: PFOS) and urinary excretion (UE; PFOA, PFHxS).

Soil amendments reduce PFAS bioaccumulation in Eisenia fetida following exposure to AFFF-impacted soil.

The efficacy of RemBind® 300 to immobilize per- and polyfluoroalkyl substances (PFAS) in aqueous film forming foam (AFFF)-impacted soil (∑ PFAS 1280-8130 ng g; n = 8) was assessed using leachability (ASLP) and bioaccumulation (Eisenia fetida) endpoints as the measure of efficacy. In unamended soil, ∑ PFAS leachability ranged from 26.0 to 235 μg l, however, following the addition of 5% w/w RemBind® 300, ∑ PFAS leachability was reduced by > 99%.

Impact of precursors and bioaccessibility on childhood PFAS exposure from house dust.

This study investigated the impact of precursors and bioaccessibility on childhood per- and polyfluoroalkyl substances (PFAS) exposure in house dust (n = 28) from Adelaide, Australia. Sum PFAS concentration (∑) ranged from 3.0 to 2640 μg kg with PFOS (1.