Publications by authors named "Rubing Wu"
Purpose: Myocardial fibrosis (MF) after acute myocardial infarction (AMI) ultimately results in heart failure, which is a serious threat to human life. This study aimed to excavate critical biomarkers associated with MF after AMI.
Materials And Methods: RNA-sequencing was performed to obtain differentially expressed mRNAs (DEmRNAs), miRNAs (DEmiRNAs) and lncRNAs (DElncRNAs) in AMI and MF after AMI.
Myocardial infraction (MI) is a severe disease with great mortality. Mesenchymal stem cells-derived exosomes display protection against MI. MicroRNA-129-5p was reported to exert anti-inflammation activity by targeting high mobility group box 1 (HMGB1).
View Article and Find Full Text PDFMorbidity and mortality of heart failure (HF) post-myocardial infarction (MI) remain elevated. The aim of this study was to find potential long non-coding RNAs (lncRNAs) and mRNAs in the progression from acute myocardial infarction (AMI) to myocardial fibrosis (MF) to HF. Firstly, blood samples from AMI, MF, and HF patients were used for RNA sequencing.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers isolated exosomes from the plasma of AF patients and healthy individuals, confirming that AF-derived exosomes contained higher levels of miR-107, which affected HUVEC behavior significantly.
- * The results indicated that miR-107 delivery led to decreased cell viability and migration, increased cell apoptosis, and altered cell cycle phases by targeting specific pathways, particularly the miR-107/USP14 pathway.