Publications by authors named "Rubina Islam"
Aberrant expression of the WNT signaling pathway has been associated with cancer progression and recurrence. Research over the decades has led to development of WNT-targetable small molecules, but has faced challenges in translating to clinics. Unlike WNT/β-catenin inhibitors, WNT5A-mimicking peptide, Foxy5 has shown encouraging efficacy in impairing metastasis of cancers with low or absent WNT5A expression.
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- A study in India assessed bortezomib (BZB) and reduced doses of cytarabine in treating children with relapsed acute lymphoblastic leukemia (rALL), involving 55 participants.
- Out of those treated, 88% achieved second remission and a significant number showed low minimal residual disease after induction therapy.
- The results showed promising one-year survival rates, with 74.7% event-free survival and 79.6% overall survival in the group receiving treatment.
Karyotyping along with a 3-probe fluorescence in situ hybridization (FISH) strategy was used to risk stratify therapy in 303 children with B-cell precursor acute lymphoblastic leukaemia. Of the 166 patients risk stratified, karyotype identified 91 (55%). FISH identified all karyotypes accurately, with the exception of hypodiploidy, and risk stratified an additional 75 patients.
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