Effects of botulinum toxin A injections in spinal cord injury patients with detrusor overactivity and detrusor sphincter dyssynergia.

Objective: To evaluate the safety and effect of botulinum toxin A injection in the detrusor and external urethral sphincter in male patients with detrusor overactivity (DO) and detrusor external sphincter dyssynergia (DESD) secondary to spinal cord injury.

Methods: A multicentre trial was conducted from June 2012 to August 2015. A total of 65 spinal cord injury patients with DO and DESD participated in the study.

Cystitis glandularis: A controversial premalignant lesion.

Cystitis glandularis (CG) has been hypothesized as a potential precursor of adenocarcinoma, although this remains controversial. The present study reports data accumulated from 166 cases of cystitis glandularis with follow-up periods ranging between 0.5 and 17 years.

Effectiveness and complication rates of tension-free vaginal tape, transobturator tape, and tension-free vaginal tape-obturator in the treatment of female stress urinary incontinence in a medium- to long-term follow up. Meta-analysis of randomized controlled trials.

Objective: To evaluate the effectiveness and complications of tension-free vaginal tape (TVT), transobturator tape (TOT), and tension-free vaginal tape-obturator (TVT-O) in a medium- to long-term follow up.

Methods: We searched PubMed, EMBASE, Cochrane database, ClinicalTrials.gov, Google Scholar, and the International Continence Society (ICS) website from August to December 2012 in Guangzhou First People's Hospital, Guangzhou, China.

Transurethral enucleation and resection of the prostate vs transvesical prostatectomy for prostate volumes >80 mL: a prospective randomized study.

Objectives: To compare the efficacy and safety of transurethral enucleation and resection of the prostate (TUERP) and transvesical prostatectomy (TVP) for patients with benign prostatic hyperplasia (BPH) and prostate volumes >80 mL.

Patients And Methods: A total of 100 patients with urodynamic obstruction and prostate volume >80 mL were prospectively randomized and enrolled in the study at a tertiary hospital. Patients underwent TVP or TUERP performed by one of two surgeons with experience of a large number of cases.

[Holmium laser enucleation versus open prostatectomy for large volume benign prostatic hyperplasia: a meta-analysis of the therapeutic effect and safety].

Objective: To compare holmium laser enucleation (HoLEP) versus open prostatectomy (OP) for large volume benign prostatic hyperplasia.

Methods: The randomized controlled trials (RCTs) pertaining to HoLEP and OP for management of large volume benign prostatic hyperplasia were retrieved from Medline and Embase. Meta-analysis was performed using Review Manager 5.

Lost to follow-up in high level evidence-based studies related to the surgical management of lower urinary tract symptoms secondary to benign prostatic enlargement: does it matter?

Aims: A contemporary review of the literature on benign prostatic hyperplasia (BPH) for lost to follow-up (LTF) rate was performed to evaluate the significance of LTF in the surgical management of lower urinary tract symptoms (LUTS) secondary to benign prostatic enlargement (BPE).

Methods: Randomized clinical trials (RCT level I) on the surgical treatment of LUTS secondary to BPE, with at least 12-month follow-up, from 1/1995 to 10/2010 were searched on PUBMED. Data reviewed included types of study, number of participating centers or hospitals, sample size calculation, surgical techniques, power calculation, estimated dropout rate, duration of follow-up, rate and reasons for LTF.

Prolapse follow-up at 5 years or more: myth or reality?

Objectives: To study the loss to follow-up (LTF) rate in level I/II evidence-based studies related to the surgical management of pelvic organ prolapse (POP).

Methods: Randomized controlled trials (level I) or nonrandomized but prospective studies (level II) related to the surgical treatment of POP from January 1995 to November 2010 were searched in PubMed. Data reviewed included types of study, number of participating centers, sample size calculation, surgical techniques, power calculation, estimated dropout rate, duration of follow-up, and rate and reasons for LTF.

Urodynamically diagnosed detrusor hypocontractility: should transurethral resection of the prostate be contraindicated?

Background: Patients with benign prostatic hyperplasia (BPH) suffering from hypocontractile detrusor were generally regarded unsuitable for surgery. This prospective study is to evaluate the efficacy of transurethral resection of the prostate (TURP) on BPH patients diagnosed detrusor hypocontractility on urodynamic study (UDs).

Methods: Twenty patients were included in the study with mean age of 74.

Level I/II evidence-based studies of surgical treatment of female stress urinary incontinence: patients lost to followup.

Purpose: We determined the rate of patients lost to followup in level I/II evidence-based studies of surgical management of stress urinary incontinence in women.

Materials And Methods: Randomized clinical trials (level I) or nonrandomized but prospective studies (level II) related to surgical treatment of stress urinary incontinence in women from January 1995 to November 2009 were searched on PubMed®. Data reviewed included study type, number of participating centers or hospitals, sample size calculation, surgical techniques, power calculation, estimated dropout rate, followup duration, and rate of and reasons for loss to followup.

[The effect of prostatectomy on nocturia in patients with benign prostatic hyperplasia].

Objective: To explore the effect of prostatectomy on nocturia in patients with benign prostatic hyperplasia (BPH).

Methods: The data of patients who had received prostatectomy for BPH between June 2006 and December 2007 were collected. Nocturia severity was assessed preoperatively and 3 to 6 months after prostatectomy by the number of nocturia events, the time from falling sleep to the first awakening to void (hours of undisturbed sleep, HUS), the score of the nocturia quality of life (N-QOL) questionnaire, the International Prostatic Symptom Score (IPSS) and the quality of life (QOL) score.

A randomized trial of transvesical prostatectomy versus transurethral resection of the prostate for prostate greater than 80 mL.

Objectives: We compared the safety and efficacy of transvesical prostatectomy (TVP) and transurethral resection of the prostate (TURP) for prostate greater than 80 mL in a prospective randomized trial.

Methods: Eighty patients with urodynamic obstruction and prostate volume >80 mL were prospectively randomized and assigned to TVP or TURP. Patients were assessed preoperatively and followed up at 3 and 12 months postoperatively.

Antibacterial therapy improves the effectiveness of prostate cancer detection using prostate-specific antigen in patients with asymptomatic prostatitis.

Objectives: To improve prostate cancer (PC) detection accuracy among patients with a prostate-specific antigen (PSA) above 4.0 ng/ml and asymptomatic prostate inflammation.

Materials And Methods: A total of 136 patients with PSA ranging from 4.

Protective effect of ganoderan on renal damage in rats with chronic glomerulonephritis.

Purpose: To investigate the protective effect of ganoderan on renal damage in rat models with chronic glomerulonephritis induced by adriamycin.

Methods: 48 healthy Sprague-Dawley rats were randomly divided into three groups: control, nephritic model and ganoderan treatment groups. Changes of the following indices in the three groups were observed 6 weeks after treatment: 24-hour urine protein, albumen, serum creatinine, cholesterol.

cDNA macroarray for analysis of gene expression profiles in prostate cancer.

Background: Early diagnosis and timely treatment are important for improving therapeutic efficiency of prostate cancer. DNA array is a new bio-technology for disease diagnosis. This study was conducted to diagnose prostate cancer with cDNA macroarray and analysis gene expression profiles of some selective genes in prostate cancer.

[The therapeutic efficacy for ED patients treated with low dosage of PGE1].

Objectives: To evaluate the efficacy of intrameatal application of low dosage alprostadil (PGE1) cream (300 mcg) for the treatment of erectile dysfunction (ED).

Methods: A total of 43 ED patients were selected in the study based on the inclusion criteria. All of the patients signed informed consent forms and entered a 4-week open-label clinical study.