Publications by authors named "Rubia Castro Fernandes Melo Reis"
Article Synopsis
- * The review discusses synthetic methods to create over 100 bioactive derivatives of eugenol and related compounds, emphasizing their effectiveness against different types of pathogens.
- * Key findings suggest that changing the structure of these compounds can significantly enhance their antimicrobial properties, paving the way for future research in developing new antimicrobial drugs.
Article Synopsis
- Chagas disease (CD) affects approximately 8 million people across 21 countries and primarily relies on two drugs, which have significant limitations such as low cure rates, high toxicity, and rising resistance from the parasite T. cruzi.
- Recent research identified a new compound (1,2,3-triazole derivative 35) that showed promising in vitro and in vivo activity against T. cruzi, leading to the development of new derivatives that displayed even more potent antiprotozoal properties.
- Among these, compounds 26 and 27 exhibited significantly lower toxicity to healthy cells compared to standard treatments and displayed effective trypanocidal activity, suggesting a potential new avenue for treating Chagas disease despite their mechanism of action not being
New miconazole-based azoles derived from eugenol show activity against Candida spp. and Cryptococcus gattii by inhibiting the fungal ergosterol biosynthesis.
Eur J Med Chem
August 2023
This work describes the design, synthesis and antifungal activity of new imidazoles and 1,2,4-triazoles derived from eugenol and dihydroeugenol. These new compounds were fully characterized by spectroscopy/spectrometric analyses and the imidazoles 9, 10, 13 e 14 showed relevant antifungal activity against Candida sp. and Cryptococcus gattii in the range of 4.
View Article and Find Full Text PDFGlucosyl-1,2,3-triazoles derived from eugenol and analogues: Synthesis, anti-Candida activity, and molecular modeling studies in CYP-51.
Chem Biol Drug Des
November 2021
This work describes the synthesis, anti-Candida, and molecular modeling studies of eighteen new glucosyl-1,2,3-triazoles derived from eugenol and correlated phenols. The new compounds were characterized by combined Fourier Transform Infrared, H and C nuclear magnetic resonance and spectroscopy of high-resolution mass spectrometry. The synthesized compounds did not show significant cytotoxicity against healthy fibroblast human cells (MCR-5) providing interesting selectivity indexes (SI) to active compounds.
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