Publications by authors named "Rubhan Chandran"
The management of hemophilia A has undergone a remarkable revolution, in line with technological advancement. In the recent past, the primary concern associated with Factor VIII (FVIII) concentrates was the risk of infections, which is now almost resolved by advanced blood screening and viral inactivation methods. Improving patients' compliance with prophylaxis has become a key focus, as it can lead to improved health outcomes and reduced health care costs in the long term.
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- - Caffeine has therapeutic properties for treating conditions like apnea, cellulite, and pain, and shows promise in neuroprotective roles against Parkinson's and Alzheimer's diseases; however, delivering it through the skin (transdermal) has been difficult due to its hydrophilic nature.
- - The study explored using hydrogel microneedles to enhance caffeine's transdermal delivery, examining how factors like the molecular weight of copolymers and sodium bicarbonate concentration impacted the hydrogel's swelling and mechanical integrity.
- - Results showed that higher molecular weight and sodium bicarbonate concentrations improved swelling, and that using an applicator combined with thumb pressure greatly increased the skin penetration efficiency of the microneedles, allowing for effective caffeine