Publications by authors named "Rubens A O Menezes"
Background: The innate immune response plays an important role during malaria. Toll-like receptors (TLR) are capable of recognizing pathogen molecules. We aimed to evaluate five polymorphisms in TLR-4, TLR-6, and TLR-9 genes and their association with cytokine levels and clinical parameters in malaria from the Brazil-French Guiana border.
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- The study investigates the role of TREM-1 gene polymorphisms in the immune response to malaria, specifically in patients infected with Plasmodium vivax in the Brazilian Amazon.
- Researchers analyzed blood samples from 76 infected individuals and 144 healthy controls, measuring various cytokines and antibodies to understand their relationship with TREM-1 polymorphisms.
- Results showed significant associations between certain gene variants and increased levels of inflammatory cytokines in malaria patients, suggesting these SNPs could influence the severity of the disease.
Background: Plasmodium vivax malaria is an important public health issue in the Amazon region, and it accounts for approximately 84 % of cases of the disease. Migration across the border between Brazil and French Guiana contributes to the maintenance of the disease. The aim of this study was to evaluate the therapeutic and parasitological responses of patients with P.
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