Assessment of Acute-Phase Protein Response Associated with the Different Pathological Forms of Bovine Paratuberculosis.

In this study, the concentrations of two acute-phase proteins (APPs), haptoglobin (Hp) and serum amyloid A (SAA), were quantitatively assessed in serum samples from cattle naturally infected with paratuberculosis (PTB). APP profiles were compared across 190 animals classified according to the different pathological forms associated with infection: uninfected ( = 59), with focal lesions ( = 73), multifocal lesions ( = 19), and diffuse paucibacillary ( = 11) and diffuse multibacillary lesions ( = 28). Our results showed a significant increase in both APPs in infected animals compared to the control group, with differences depending on the type of lesion.