Publications by authors named "Ruben da Silva"
Background: The use of peptides as drug carriers across the blood-brain barrier (BBB) has increased significantly during the last decades. PepH3, a seven residue sequence (AGILKRW) derived from the α-helical domain of the dengue virus type-2 capsid protein, translocates across the BBB with very low toxicity. Somehow predictably from its size and sequence, PepH3 is degraded in serum relatively fast.
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- The study details the crystal structures of a fragment of human SP-D that interacts with specific sugars from Salmonella bacteria.
- The findings show that this protein preferentially targets a conserved sugar pair (Hep-Kdo) found in the bacteria's structure but can also adapt to bind different sugar configurations when necessary.
- This research highlights the versatility of hSP-D in recognizing various bacterial components, which could have implications for understanding how the immune system identifies and responds to pathogens.