Publications by authors named "Ruben Lattuca"
Article Synopsis
- Mammalian ribosomal RNA (rRNA) has over 220 modifications, but how these modifications are regulated across tissues and conditions is still unclear.
- Researchers used direct RNA sequencing to analyze rRNA modifications in humans and mice, discovering tissue- and developmental stage-specific modification patterns, including new sites not previously documented.
- They established "epitranscriptomic fingerprinting," a method enabling accurate identification of tissues and tumor types, and showed that rRNA modification patterns could effectively distinguish normal and tumor samples in lung cancer patients with minimal data.
Ribosomes are essential nanomachines responsible for protein production. Although ribosomes are present in every living cell, ribosome biogenesis dysfunction diseases, called ribosomopathies, impact particular tissues specifically. Here, we evaluate the importance of the box C/D snoRNA-associated ribosomal RNA methyltransferase fibrillarin (Fbl) in the early embryonic development of Xenopus laevis.
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