TiO nanoparticle coatings on glass surfaces for the selective trapping of leukemia cells from peripheral blood.

Photodynamic therapy (PDT) using TiO nanoparticles has become an important alternative treatment for different types of cancer due to their high photocatalytic activity and high absorption of UV-A light. To potentiate this treatment, we have coated commercial glass plates with TiO nanoparticles prepared by the sol-gel method (TiO -m), which exhibit a remarkable selectivity for the irreversible trapping of cancer cells. The physicochemical properties of the deposited TiO -m nanoparticle coatings have been characterized by a number of complementary surface-analytical techniques and their interaction with leukemia and healthy blood cells were investigated.

Synthesis and characterization of porous structures of rutile TiO /NaTiO/NaTiO for biomedical applications.

This method involves the use of molding, pressing and sintering techniques applied to different powder mixtures of TiO with sodium bicarbonate NaHCO (15 wt% and 30 wt% NaHCO), to obtain porous structures of rutile TiO/NaTiO/NaTiO and NaTiO/NaTiO for possible biomedical implant applications. The method validation includes X-ray diffraction patterns (XRD) analysis refined by the Rietveld method using X'Pert HighScore Plus. The surface morphology was observed by using a scanning electron microscopy (SEM) equipped with an energy dispersive spectrometer (EDS), and, finally, a Chinese hamster ovary (CHO) cell line was cultured with the porous structures to determine the effect of material composition on the cellular response using a LDH cytotoxicity assay.