Publications by authors named "Ruben Jara Rubio"

Article Synopsis
  • The study investigates the impact of genetic variations (SNPs) in the ACE2 and related genes on the severity of COVID-19 among patients, revealing some SNPs provide protective effects while others increase risk of severe outcomes.
  • A total of 318 COVID-19 patients were categorized based on their symptoms, with analyses highlighting the relationship between specific SNPs and disease severity, alongside traditional risk factors like age and comorbidities.
  • Key findings show that certain ACE2 SNPs can significantly influence disease progression, with two SNPs linked to protective effects and two others associated with higher risk for hospitalization and severe illness.
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Donation after circulatory death (DCD) represents a promising opportunity to overcome the relative shortage of donors for heart transplantation. However, the necessary period of warm ischemia is a concern. This study aims to determine the critical warm ischemia time based on in vivo biochemical changes.

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Background: The actual effects of oxygen therapy on patients who have suffered a stroke are still unknown, and its recommendation as a routine measure in emergency services remains controversial. The aim of this study is to determine the effect of hyperoxia in functional recovery in patients with ischemic stroke who underwent intra-arterial mechanical thrombectomy (IAMT).

Methods: A prospective observational cohort study that included all adult patients consecutively admitted to the intensive care unit (ICU) due to an ischemic stroke in the anterior cerebral circulation and following an IAMT intervention, between 2010 and 2015.

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Objectives: The aim of this study was to measure the level of preoperative anxiety in patients scheduled for cardiac surgery, identify any influencing clinical factors, and assess the relationship between anxiety and postoperative morbidity.

Design: A prospective and consecutive study.

Setting: A single university hospital.

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Remodelling in the atria could appear as a result of hypertension, diabetes or ischaemic heart disease. Galectin-3 (Gal-3) is a mediator of profibrotic pathways and a potential biomarker of cardiac remodelling. We prospectively recruited consecutive patients undergoing elective cardiac surgery.

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Aims: Atrial fibrillation (AF) is associated with an increased morbidity and mortality after cardiac surgery. Von Willebrand factor (vWF) has been proposed as a biomarker of endothelial damage/dysfunction. We hypothesized that vWF levels could be used as valuable biomarker for AF occurrence after cardiac surgery.

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Introduction: Atrial fibrillation (AF) has an incidence rate of approximately 30% and is the most frequent arrhythmia following heart surgery. Factors such as inflammation, the presence of heart fibrosis, stress and cardiomyocyte apoptosis, have all been associated with AF.

Objectives: We believe that atrial remodelling is a pre-existent process in patients with post-surgical AF.

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We report a case of acute aortic syndrome in a 64-year-old man who presented with chest pain and hypotension. His electrocardiogram and cardiac troponins were normal. Computed tomography showed hemopericardium of 2.

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Article Synopsis
  • About 29% of patients developed post-surgical AF, leading to longer hospital stays, and higher preoperative hsTnT levels were found in these patients, indicating a risk factor for AF.
  • In multivariate analysis, only high pre-surgery hsTnT levels significantly predicted AF, showing a strong association (Odds Ratio of 4.27) while NT-proBNP did not have a statistically significant relationship.
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The low cardiac output syndrome following cardiopulmonary bypass is characterized by poor left ventricular contractibility that requires the support of high doses of vasoactive drugs, intra-aortic balloon pump, and sometimes makes it impossible to disconnect the extracorporeal circulation. We report 5 cases in which a "recently created" device in left ventricular support was inserted, the Impella Recover (Impella CardioSystems AG, Aachen, Germany) due to cardiogenic shock at the end of the surgery. Four of these patients recovered their heart function and the ventricular support could be removed after 70+/-55 h.

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