Publications by authors named "Ruben G Orihuela"
Environ Health Perspect
August 2013
Article Synopsis
- Cancer stem cells (CSCs) are influenced by their microenvironment, and normal stem cells (NSCs) from human prostate can be converted into CSC-like cells by nearby malignant epithelial cells (MECs) transformed by arsenic.
- Research aimed to determine if this recruitment process also occurs with NSCs and MECs transformed by other carcinogens, specifically cadmium and N-methyl-N-nitrosourea (MNU).
- Results showed that NSCs co-cultured with cadmium-transformed MECs (Cd-MECs) exhibited features typical of cancer cells, including increased invasiveness and altered gene expression, whereas co-culture with MNU-transformed MECs did not induce similar changes, highlighting the specificity of the recruitment
