Publications by authors named "Ruben Foj"
The tumour necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the tumour necrosis factor ligand family and has been shown to be overexpressed in tumoral cells together with the fibroblast growth factor-inducible 14 (Fn14) receptor. TWEAK-Fn14 interaction triggers a set of intracellular pathways responsible for tumour cell invasion and migration, as well as proliferation and angiogenesis. Hence, modulation of the TWEAK-Fn14 interaction is an important therapeutic goal.
View Article and Find Full Text PDFBackground: Sublingual immunotherapy (SLIT) has been deployed in humans and dogs; to the best of the authors' knowledge, there are no published studies about the use of SLIT in cats.
Objectives: Evaluate the clinical efficacy of SLIT in atopic cats sensitized to dust and storage mites, assessing immunological changes associated with SLIT treatment.
Animals: Twenty-two client-owned cats with clinical signs compatible with feline atopic dermatitis (fAD) and serum allergen-specific immunoglobulin (Ig)E against house dust and storage mites.
Article Synopsis
- GRP94 is an important protein that helps cells survive stress, especially in breast cancer, and its high levels can lead to brain tumors.
- Scientists studied how changing the environment around cells affects GRP94 and its role in causing brain metastasis (BM) in breast cancer patients.
- The study found that removing GRP94 makes tumor cells less able to survive without glucose, and treating models with hydroxychloroquine can help stop tumor growth, suggesting a new way to prevent brain metastasis.
Brain metastasis is a devastating problem in patients with breast, lung and melanoma tumors. GRP94 and FN14 are predictive biomarkers over-expressed in primary breast carcinomas that metastasized in brain. To further validate these brain metastasis biomarkers, we performed a multicenter study including 318 patients with breast carcinomas.
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