Combined Evaluation of Nociceptive Detection Thresholds and Evoked Potentials during Conditioned Pain Modulation: A Feasibility Study.

Deficient top-down inhibitory control via diffuse noxious inhibitory control (DNIC) is a mechanism known to be responsible for the maintenance and development in several chronic pain syndromes. Experimentally, DNIC is often induced by conditioned pain modulation (CPM) paradigms such as a Cold Pressor Test (CPT). Recently, a method called the NDT-EP method has been developed with the aim to evaluate the nociceptive function, which it does via simultaneous tracking of nociceptive detection thresholds (NDT) and evoked potentials (EP).