[The content of rosette-forming neutrophils and lysozyme in patients with Q-fever].

The article deals with the results of study of 35 patients with Q-fever and 30 donors to determine the content of rosette-forming neutrophils, lysozyme activity of blood and saliva. On the second week of disease it was revealed the activation of compensative immune mechanisms and on third and fourth week inhibition of these mechanisms.

[The role and biological significance of toll-like receptors in the anti-infectious resistance of the organism].

Modem conceptions of the role of toll-like receptors (TLR) in the innante immunity mechanisms realization and data on the interaction between TLR and pattern-associated molecular proteins of microbial or endogenic origin are presented in the review.

[Interferon therapy of infectious diseases: the state of the problem and prospects].

The data contained in literature and obtained in our own investigations, aimed at the evaluation of the significance of interferon preparations for the correction of immunological disturbances are presented. A special place is given to the role of mild medicinal forms of interferon, the necessity of their use is grounded and good prospects for their inclusion into the complex therapy of infectious diseases are shown.

[Effect of the treatment of relapsing bronchitis in children with combined interferon preparations applicated by different methods].

The clinico-immunological effect and significance of the rectal and inhalation methods of the application of recombinant IFN-alpha2 with complex immunoglobulin preparation (CIP) in the treatment of relapsing bronchitis in children have been determined. The determination of the levels of interferon activity in buccal secretions and in venous blood permits the objective evaluation of the immune responsiveness of the body and the treatment effect. The immunocorrecting action of the combined immunobiological preparation (recombinant IFN-alpha2 and CIP) is manifested by an increased level of endogenic interferon and the stimulation of phagocytic activity.

[Influence of cytokine preparations on the in vitro resistance of bacteria to antibiotics].

Recombinant tumor necrosis factor-alpha and gamma-interferon were found in vitro to increase the sensitivity of bacteria to antibiotics both alone and in combination; alpha2-interferon decreased this sensitivity.

[The pathogenetic role of the infection component in children with lymphadenopathy under modern conditions].

Apart from lymphadenopathy types observed in well-known diseases (oncology and hematology pathologies, systemic lesions of connective tissues, tuberculosis, brucellosis, infection mononucleosis, toxoplasmosis, AIDS and other specific processes), there is an extensive group of lymphadenopathy (up to 70% of all disease cases), whose cause cannot be diagnosed by using the routine examination schemes. This was reflected in the diagnosis of "lymphadenopathy of unverified etiology" according to the MKB-1 now in force. Investigations of the role (in etiopathogenesis) of unverified lymphadenopathy types as observed in children with the infection component as well as optimization of their diagnosis and treatment schemes are elucidated in the paper.

[Interferon-based immunobiological preparations. An outlook of their use in the treatment of patients with infections].

The paper contains the generalizing results of many-year research related with using various ready-made medication forms (RMF) of human genetic-engineering interferon-alpha 2 and of methods of its administration into the body. Extensive clinical materials were made use of to show convincingly that the most effective therapy for infectious diseases is ensured within a short time period and with a consequent long-term rehabilitation effect by using separate RMFs and methods of application of interferon-alpha 2, when their impact on the lesion focus is monitored by the parameters of the cellular-and-humoral chains of the general and local immunity. It is noteworthy, that a selection of RMF adequate for an actual nosologic form or of an administration method can reduce the medication dose of interferon-alpha 2 (thus, the incidence of complications to the drug goes down), it can also eliminate the influenza-like syndrome and production of autoantibodies related with the intramuscular administration of interferon-alpha 2, besides, it essentially prolongs the presence of interferon-alpha 2 in the body.

[Specific biological features of opportunistic bacteria determining dysbacteriosis in the composition of the large intestine normal microflora].

Dysbiotic manifestations in the gastrointestinal tract are widely spread. They are characterized by a prolonged, persistent course with the tendency to transition to the chronic form and poorly respond to corrective treatment. The occurrence of high concentrations is 70% for Klebsiella oxytoca, while for K.

[Formation of intestinal microflora in children during the first year of their life].

In 525 young children the state of intestinal microbiocenosis was studied every month of the first year their life. The study revealed that the process of the microflora formation lasted throughout the first year of their life and was characterized by dysbiotic disturbances. During this period the aggravation of dysbiotic changes in the intestine of these children on months 3, 6-7 and 11-12 was of particular importance.

[Age-dependent characteristics of intestinal microbiocenosis in Kemerovo residents].

In 873 residents of Kemerovo aged 1-60 years and older the microflora of the large intestine was studied. The study revealed that in all examined subjects dysbiotic changes in the composition of normal microflora were observed. More profound disturbances of microbiocenosis were found in children aged 1-2 years, in adolescents and in adults over 60 years of age.

[Endogenous regulatory peptides, interferons and cytokines as adaptogens in exposure of the body to adverse environmental factors].

The authors summarize data on the efficacy of various prefabricated recombinant interferons against virus, bacterial, and chlamydial infections, and in unfavorable environments. The spaceflight factors were shown to have a negative influence on natural killers in the human body providing the immunological resistance and defence not only from foreign microorganisms but also the body cells transformed because of a virus infection or malignancy. Entalferon awakes a particular interest for its convenience in extreme conditions, space flight included.

[Cytokines in the immunorehabilitation of infectious patients].

For the first time in Russia the authors have defined an infectious process of Astrakhan rickettsiosis hemorrhagic fever attended by hyper- and hypoproduction of interferon g and its aftereffects. Reaferon and gammaferon therapy have proved to be very effective in fast normalisation of the immunology index. Enthalferon pills greatly reduced the morbidity rate in servicemen in rotaviral infections.

[Study of antiinfectious potential of recombinant tumor necrosis factor-alpha].

Tumor necrosis factor-alpha (TNF) was shown to have an antiinfectious effect on murine and rat models of viral, bacterial and parasitic infections. The effective antiinfectious dose of TNF was determined to be 10(2)-10(3) U/kg body weight. TNF, interferon, and antibiotics were demonstrated to potentiate the antibacterial effect of each.

[Use of recombinant alpha2-interferon and a complex immunoglobulin preparation for the treatment of chlamydiosis in pregnancy women].

The comparative study of the efficiency of using erythromycin and the combination of recombinant alpha 2-interferon with complex immunoglobulin preparation (CTP) for the treatment of chlamydiosis in pregnant women was made. 31 patients (group 1) received erythromycin orally in doses of 500 mg twice a day for 15-14 days. 30 other pregnant women were prescribed vaginal suppositories containing 300 mg.

[A comparative study of the information value of the immunofluorescence and immunochromatographic identification of Chlamydia trachomatis antigens in smear material from the cervical canal and of the cytological picture of a vaginal discharge in pregnant women].

The cytological picture of the vaginal discharge and scrape material, obtained from 30 pregnant women of the control group (not infected with C.trachomatis) and 61 pregnant women with chlamydiosis; of these, in 42 women the comparative identification of chlamydiae by the methods of direct immunofluorescence and immunochromatography was carried out. Direct immunofluorescence was carried out with the use of a set of reagents "MicroTrak" (USA) and immunochromatographic identification was made with the use of a set of reagents "Clearview Chlamydia" (Britain).

[The use of "aluminal" stain in dermatology and venereology. I. Indication of protein fractions after disc electrophoresis].

A new method for staining the electrophoregrams is described. After disk electrophoresis the gels are treated in a solution with 0.01-0.