Assessment of Phenol and Antioxidant Content of Olive Varieties and Their Potential Health Benefits for Colon Health.

In this study, four different olive fruit and leaf varieties collected in Jordan were assessed for quality using both chemical and biological methods. To quantify the phenol and antioxidant content in the olive fruit and leaf extracts, a validated UV method was employed. The antioxidant activity and total phenolic content of fruit and leaf extracts of the olive varieties were measured using the DPPH radical scavenging assay and Folin-Ciocalteu colorimetric method, respectively.

Current Trends on Solid Dispersions: Past, Present, and Future.

Solid dispersions have achieved significant interest as an effective means of enhancing the dissolution rate and thus the bioavailability of a range of weakly water-soluble drugs. Solid dispersions of weakly water-soluble drugs with water-soluble carriers have lowered the frequency of these problems and improved dissolution. Solid dispersion is a solubilization technology emphasizing mainly on, drug-polymer two-component systems in which drug dispersion and its stabilization is the key to formulation development.

Cysteines and Disulfide-Bridged Macrocyclic Mimics of Teixobactin Analogues and Their Antibacterial Activity Evaluation against Methicillin-Resistant (MRSA).

Teixobactin is a highly potent cyclic depsipeptide which kills a broad range of multi-drug resistant, Gram-positive bacteria, such as Methicillin-resistant (MRSA) without detectable resistance. In this work, we describe the design and rapid synthesis of novel teixobactin analogues containing two cysteine moieties, and the corresponding disulfide-bridged cyclic analogues. These analogues differ from previously reported analogues, such as an Arg-teixobactin, in terms of their macrocyclic ring size, and feature a disulfide bridge instead of an ester linkage.