Depigmented, Polymerized Cat Epithelium Extract Is Safe and Improves Rhinitis and Asthma Symptoms in Cat-Allergic Patients: A Real-World Retrospective Study.

Introduction: Exposure to cat allergens is often difficult to avoid. Here, we evaluated the safety and effectiveness of a depigmented, polymerized cat epithelium extract (Dpg-pol-cat) for the treatment of allergic rhinoconjunctivitis and asthma.

Methods: Real-world, retrospective study of patients ≥12 years of age with cat allergy and moderate to severe allergic rhinitis/rhinoconjunctivitis, with or without asthma, who started allergen immunotherapy (AIT) with Dpg-pol-cat extract during routine visits to the Allergy Department.

Use of micro-computed tomography to monitor olive fruit damage caused by three insect pests.

A complete three-dimensional reconstruction of the internal damage (oviposition holes, entry and exit galleries, cavities caused by fungal infection) of three destructive pests of olive fruit was obtained using micro-computed tomography. In the case of the olive fruit fly (Bactrocera oleae), complete reconstruction of the galleries was achieved. The galleries were colour-coded according to the size of the internal lumens produced by larval instars.

Knowledge, practices and barriers to access sexual health of women in the menopausal stages: a cross-sectional study with Brazilian gynecologists.

Background: Sexual health access and care for women in the menopausal stages face significant barriers, presenting deficits in relation to diagnosis and treatment. Although epidemiological data indicate high prevalence of problems related to sexual health in this population, traditionally, the theme is not discussed in health care settings. This study aimed to analyze knowledge, practices and barriers to access sexual health of women in the menopausal stages in the context of women's health care in Brazil.

Phenotypic plasticity of a winter-diapause mechanism copes with the effects of summer global warming in an ectothermic predator.

To adapt to changes in temperature, animals tend to invest more energy in thermal tolerance to enhance survival, which can have simultaneous costs on plastic traits. Would a decrease in genetic variability, due to global warming, affect the ability of populations with existing metabolic regulatory mechanisms to cope with extreme temperatures? To address this question, we conducted a series of experiments based on the A1B scenario of global warming, assessing within-population genetic variance in (a) morphological traits, (b) metabolic rate allometries, and (c) survival of a winter-diapausing predator ectotherm. Our study focused on the lacewing species , using both exogamic and endogamic artificial genetic lines.

Clavulanic Acid Is a Leading Culprit Beta-Lactam in Immediate Allergic Reactions to Penicillins.

Purpose: Clavulanate, a beta-lactam associated with amoxicillin, is frequently prescribed in patients at all ages. Recent data implicate amoxicillin-clavulanate in up to 80% of beta-lactam allergy cases. We assessed clavulanate's role in inducing allergic reactions to this combination treatment, with a focus on selective immediate reactions.

Vegetation Cover Management and Landscape Plant Species Composition Influence the Chrysopidae Community in the Olive Agroecosystem.

Habitat manipulation through the promotion of semi-natural habitats such as cover and patch vegetation is a possible means of offsetting the negative impacts of the agricultural practices. A baseline situation is crucial before any successful habitat manipulation is attempted. We studied the effects that current vegetation cover management practices have on plant composition and the potential attraction that the plant families from the semi-natural habitats could have on the Chrysopidae community, a key pest control agent, in five olive farms in Granada (Spain).

Sensitisation to Pollen Allergens in Children and Adolescents of Different Ancestry Born and Living in the Same Area.

Background: Allergy can start at early ages, with genetic and environmental factors contributing to its development.

Aim: The study aimed to describe the pattern of sensitisation and allergy in children and adolescents of Spanish versus Moroccan ancestry but born in the same rural area of Spain.

Methods: Participants were children and adolescents (3-19 years) of Spanish or Moroccan descent, born in Blanca, Murcia (Spain).

One in a Million: Genetic Diversity and Conservation of the Reference Population in Europe from the Sado Estuary (Portugal).

The production of cupped oysters is an important component of European aquaculture. Most of the production relies on the cultivation of the Pacific oyster , although the Portuguese oyster represents a valuable product with both cultural and economic relevance, especially in Portugal. The authors of the present study investigated the genetic diversity of Portuguese oyster populations of the Sado estuary, both from natural oyster beds and aquaculture facilities, through gene fragment sequencing.

Abundance and Population Decline Factors of Chrysopid Juveniles in Olive Groves and Adjacent Trees.

Numerous species of the family Chrysopidae, commonly found in agroecosystems, whose larvae predate on several pests of economic importance, are regarded as biological control agents. Their abundance and diversity are influenced by vegetation cover, although little is known about the effects of semi-natural habitats on their populations. The objective of this study is to gain a better understanding of the relationship between the trees in semi-natural habitats adjacent to olive groves, juvenile stages of the family Chrysopidae and factors influencing their population decline, which is crucial for an effective habitat management program aimed at conserving these important predators.

Late Summer Oviposition of Green Lacewings (Neuroptera: Chrysopidae) on Olive Groves and Adjacent Trees.

In this study, we assess how chrysopids (generalist predators widely used as biological control agents) use olive, almond, oak, and pine trees for oviposition. We sampled clutches of chrysopids from tree canopies in August 2016 and 2017. Additionally, we checked the stage (alive, predated, emerged, or parasitized) and the site (upper side, edge, or underside of leaves) and mode (single and cluster clutches) for oviposition in every clutch.

The potential role of pharmacogenomics and biotransformation in hypersensitivity reactions to paracetamol.

Purpose Of Review: The aim of the present review is to discuss recent advances supporting a role of paracetamol metabolism in hypersensitivity reactions to this drug.

Recent Findings: Recent developments in the identification of novel paracetamol metabolites, as well as in allele frequencies and functional effects of genetic variation leading to the bioavailablity of reactive paracetamol metabolites, have led to the identification of potential pharmacogenomic and metabolomic targets in studies seeking mechanisms involved in hypersensitivity reactions caused by this drug. Particularly relevant are identification of araquidonate metabolites, identification of specific-binding sequences for reactive paracetamol metabolite-protein adducts, and studies on the frequencies and the functional impact of duplication or multiduplication of genes involved in the formation of reactive metabolites, as well as complete gene deletion or deleterious mutations in genes involved in the detoxification of paracetamol reactive metabolites.

Acetyl Salicylic Acid Challenge in Children with Hypersensitivity Reactions to Nonsteroidal Anti-Inflammatory Drugs Differentiates Between Cross-Intolerant and Selective Responders.

Background: Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) in children are becoming a great concern. Most studies have focused on adults, with noted discrepancies observed in the classification of hypersensitivity reactions to NSAIDs in children when compared with adults.

Objective: To phenotype a group of children with hypersensitivity reactions to NSAIDs, including paracetamol, and analyze the degree of agreement with the entities reported in adults and how they fit the proposed classifications.

Oral Immunotherapy for Food Allergy: A Spanish Guideline. Immunotherapy Egg and Milk Spanish Guide (ITEMS Guide). Part I: Cow Milk and Egg Oral Immunotherapy: Introduction, Methodology, Rationale, Current State, Indications, Contraindications, and Oral Immunotherapy Build-up Phase.

Background And Objective: Cow milk and egg are the most frequent causes of food allergy in the first years of life. Oral immunotherapy (OIT) has been investigated as an alternative to avoidance diets. No clinical practice guidelines on the management of OIT with milk and egg are currently available.

Oral immunotherapy for food allergy: A Spanish guideline. Egg and milk immunotherapy Spanish guide (ITEMS GUIDE). Part 2: Maintenance phase of cow milk (CM) and egg oral immunotherapy (OIT), special treatment dosing schedules. Models of dosing schedules of OIT with CM and EGG.

Introduction: Cow's milk and egg are the most frequent causes of food allergy in the first years of life. Treatments such as oral immunotherapy (OIT) have been investigated as an alternative to avoidance diets. No clinical practice guides on the management of OIT with milk and egg are currently available.