Sodium Ion Diffusion Behavior in Multiple Open/Closed Pore Ratios of Novel β-Cyclodextrin-Derived Hard Carbon Anode Materials.

Plateau-dominated hard carbon with a high rate of performance is challenging to obtain, and the in-depth mechanism of pore structure on the diffusion of sodium ions remains unclear. In this study, a facile liquid-phase molecular reconstruction strategy is proposed to regulate the orientation of the β-cyclodextrin molecules and prepare spherical hard carbon with continuous and ordered pore channels. Through detailed characterization, this approach is confirmed to optimize the accumulation of Na in the dispersion region, thus improving the plateau kinetics and enhancing the utilization of closed pores.

Claudin 18.2-targeting antibody-drug conjugate CMG901 in patients with advanced gastric or gastro-oesophageal junction cancer (KYM901): a multicentre, open-label, single-arm, phase 1 trial.

Background: CMG901 is a novel first-in-class antibody-drug conjugate with a humanised anticlaudin 18.2 antibody linked to microtubule-disrupting agent monomethyl auristatin E. We aimed to assess the antitumour activity and safety of CMG901 in patients with advanced gastric or gastro-oesophageal junction cancer and other solid tumours.

Real-time lung extraction from synthesized x-rays improves pulmonary image-guided radiotherapy.

Lung tumors can be obscured in X-rays, preventing accurate and robust localization. To improve lung conspicuity for image-guided procedures, we isolate the lungs in the anterior-posterior (AP) X-rays using a lung extraction network (LeX-net) that virtually removes overlapping thoracic structures, including ribs, diaphragm, liver, heart, and trachea. Approach: 73,965 thoracic 3DCTs and 106 thoracic 4DCTs were included.

Effects of Dietary Gallic Acid on Growth Performance, Meat Quality, Antioxidant Capacity, and Muscle Fiber Type-Related Gene Expression in Broiler Chickens Challenged with Lipopolysaccharide.

In this study, broilers were selected as the research object to investigate the effects and mechanisms of dietary gallic acid (GA) supplementation on growth performance, meat quality, antioxidant capacity, and muscle fiber-related gene expression. A total of 750 one-day-old healthy 817 male crossbred broiler chickens were divided into five treatment groups, with six replicates per group. Birds in the control (CON) group and LPS-challenged treatment (LPS) group were fed a basal diet, and birds in the other three treatment groups received the basal diet with 150, 300, or 450 mg/kg added GA (GA150, GA300, GA450).

Current status of FAP-directed cancer theranostics: a bibliometric analysis.

Fibroblast activation protein (FAP) is a key molecule in the field of oncology, with significant impacts on tumor diagnosis and treatment. Importantly, it has paved the way for the development of radiotracers for quinoline-based FAP inhibitors (FAPIs), which are currently among the most promising radiotracers for PET imaging in cancer. We performed a bibliometric analysis of scientific publications related to FAP and FAPI-based radiotracers, which included the quantification and visualization of current research trends and prospects based on various bibliometric indicators.

Tough and Functional Hydrogel Coating by Electrostatic Spraying.

Hydrogel coatings impart superior surface properties to materials, but their application on large and complicated substrates is hindered by two challenges: limited wetting conditions and intricate curing processes. To overcome the challenges, lyophilized adhesive hydrogel powders (LAHPs) are developed, which consist of poly(acrylic acid-co-3-(trimethoxysilyl)propyl methacrylate) crosslinked with chitosan. These powders are electrostatic sprayed onto substrates to address wetting issues and rehydrated to form bulk hydrogel coatings to circumvent curing challenges.

Fate of vortex-synchronized state in oscillator networks with node defects.

We investigate synchronization behaviors of a Kuramoto oscillator network with a two-dimensional square-lattice configuration. We show that the oscillator network can reach a phase-locking vortex synchronized state in the long time limit starting from random initial oscillator phases sampled according to the von Mises distribution characterized by a zero mean and a finite concentration parameter. We further reveal that the stability of the vortex synchronized state is sensitive to the presence of local node defects, in contrast to the usual knowledge that oscillator networks should exhibit robustness against local perturbations.

Integrated metabolomics and microbiome analysis reveal blended oil diet improves meat quality of broiler chickens by modulating flavor and gut microbiota.

This study was to evaluate the effects of different dietary oils in chicken diets on meat quality, lipid metabolites, the composition of volatile compounds, and gut microbiota. Nine hundred female 817 crossbred broilers at one day old with an average body weight of 43.56 ± 0.

Comparison of Clinical Efficacy in the Treatment of Lumbar Degenerative Disease: Posterior Lumbar Interbody Fusion, Posterior Lumbar Fusion, and Hybrid Surgery.

Background: Numerous studies have confirmed that both posterior lumbar interbody fusion (PLIF) and posterior lumbar fusion (PLF), have their advantages and disadvantages. However, the inconsistent results of these studies make it difficult to reach a consensus on which fusion method is superior.

Objective: To compare the clinical outcomes of PLIF, PLF, and hybrid surgery combining PLIF and PLF in the treatment of lumbar degenerative disease.

Ga-FAPI-46 PET/CT in the evaluation of gliomas: comparison with F-FDG PET/CT and contrast-enhanced MRI.

This study compared Ga-FAPI-46 PET/CT, F-fluorodeoxyglucose (FDG) PET/CT, and contrast-enhanced MRI (CE-MRI) for glioma imaging, classification, and recurrence detection and explored PET parameters and molecular pathological profiles. Between June 2020 and June 2024, we prospectively enrolled patients with space-occupying lesions in the brain or previously treated gliomas. All patients underwent sequential CE-MRI, Ga-FAPI-46, and F-FDG PET/CT.

A chiral porous organic cage-modified restricted-access material achieves online analysis of serum samples containing enantiomers and positional isomers.

Restricted-access materials (RAMs) allow biological samples to directly enter the chromatographic column for analysis owing to the steric exclusion function ability for biomolecules and extraction function for small-molecule analytes, which promoting the development of rapid, efficient, and automated in vivo drug analysis. Few reports on chiral RAMs that have been used to analyze enantiomers and positional isomers in serum by direct injection in currently. In this study, a chiral porous organic cage material RCC3 was innovatively introduced into the inner surface of silica gel and modified the outer surface with polyethylene glycol to prepare a novel type of chiral RAM-RCC3, and reported the use of chiral RAM-RCC3 as a stationary phase for the separation of chiral compounds and positional isomers in blank serum using high-performance liquid chromatography.

An improved low-rank plus sparse unrolling network method for dynamic magnetic resonance imaging.

Background: Recent advances in deep learning have sparked new research interests in dynamic magnetic resonance imaging (MRI) reconstruction. However, existing deep learning-based approaches suffer from insufficient reconstruction efficiency and accuracy due to the lack of time correlation modeling during the reconstruction procedure.

Purpose: Inappropriate tensor processing steps and deep learning models may lead to not only a lack of modeling in the time dimension but also an increase in the overall size of the network.

Facile synthesis of carbon-coated CoS micro/nano-spheres as high-performance anode materials for sodium-ion batteries.

carbon-coated CoS micro/nano-spheres were successfully prepared by sulfuric calcination using the solvothermal method with glycerol as the carbon source without introducing extraneous carbon. This method prevents carbon agglomeration and avoids the cumbersome steps of the current technology. The composite demonstrates excellent sodium storage capacity as an anode material for sodium-ion batteries.

TLR10 expression in unswitched memory B associates with the disease activity of patients with systemic lupus erythematosus.

Objective: Systemic lupus erythematosus (SLE) is characterized by impaired B-cell function and a distinct B-cell phenotype. Toll-like receptor (TLR) 10 is highly expressed in human B cells and can regulate B-cell activation. Here, we examined the variations in TLR10 expression across B-cell subpopulations and its impact on the disease activity in SLE patients.

Luteolin prevents cadmium-induced PC12 cell death by suppressing the Akt/mTOR signaling pathway.

Cadmium (Cd) is an environmental pollutant that can cause neurodegenerative disorders. Luteolin (Lut) is a natural flavonoid compound. However, whether Lut protects against Cd-induced nerve cell death remains unclear.

Tissue-engineered Bicipital Autologous Tendon Patch Enhances Massive Rotator Cuff Defect Repair in a Rabbit Infraspinatus Tendon Defect Model.

Background: Massive rotator cuff defects represent an important source of shoulder pain and functional debilitation, substantially diminishing patients' quality of life. The primary treatment of massive rotator cuff defects includes complete or partial repair and patch augmentation. However, because of the tendon's limited regenerative ability, the tendon retear risk after rotator cuff defect repair is still high.

Features of Idiopathic Halitosis and Its Association With Low-Grade Systemic Inflammation.

Objectives: Idiopathic halitosis is occasionally encountered in clinical practice, yet with scarce reports. This work aimed to investigate its features and potential association with low-grade systemic inflammation (LGSI).

Methods: This retrospective study reviewed idiopathic halitosis from 2469 halitosis patients and compared them with 63 healthy controls (HCs).

Nanoscale Multipatterning Zn,Co-ZIF@FeOOH for Eradication of Multidrug-Resistant Bacteria and Antibacterial Treatment of Wounds.

The rising incidence of infections caused by multidrug-resistant bacteria highlights the urgent need for innovative bacterial eradication strategies. Metal ions, such as Zn and Co, have bactericidal effects by disrupting bacterial cell membranes and interfering with essential cellular processes. This has led to increased attention toward metal-organic frameworks (MOFs) as potential nonantibiotic bactericidal agents.

Cydonia oblonga extract mediated biosynthesis of gold nanoparticles: Analysis of its anti-oral cancer and antioxidant properties.

Here, using natural and biological macromolecules derived from Cydonia oblonga extract, we have developed a green protocol for the biogenic made Au NPs. Under ultrasonic activated conditions, the Cydonia oblonga phytomolecules were employed as an efficient green reducing agent for the Au ions to the Au NPs. Additionally, by encapsulating or capping, they allowed the Au NPs to stabilize on their own.

MUsculo-Skeleton-Aware (MUSA) deep learning for anatomically guided head-and-neck CT deformable registration.

Deep-learning-based deformable image registration (DL-DIR) has demonstrated improved accuracy compared to time-consuming non-DL methods across various anatomical sites. However, DL-DIR is still challenging in heterogeneous tissue regions with large deformation. In fact, several state-of-the-art DL-DIR methods fail to capture the large, anatomically plausible deformation when tested on head-and-neck computed tomography (CT) images.