Publications by authors named "RuRong Wang"
Background: The clinical effectiveness of enhanced recovery after surgery (ERAS) strategy, which emphasizes a comprehensive intervention without highlighting key points, seems to have reached a bottleneck. This study focuses on surgery, anesthesia and postoperative analgesia as the three key factors, to observe the related manifestations of ERAS in patients undergoing lung surgery with minimal intervention throughout the perioperative period.
Methods: All patients who underwent lung surgery by micro-invasive video-assisted thoracoscopic surgery (VATS) at Taizhou Municipal Hospital from August 2018 to August 2019 were consecutively enrolled in the study.
Article Synopsis
- Scientists studied how lung damage happens after it loses blood flow and then gets it back, especially looking at a process called pyroptosis, which makes the damage worse.
- They found that a type of immune cell in the lungs called alveolar macrophages is where most pyroptosis occurs.
- They also discovered that a substance called β-hydroxybutyrate (β-OHB) can help protect the lungs from this damage by changing how certain proteins work in the cells.
Background: Postoperative urinary retention (POUR) is a common complication of anorectal surgery. This study was to determine the incidence of POUR in anorectal surgery for benign anorectal diseases, identify its risk factors, and establish a nomogram for prediction of POUR.
Methods: A nested case-control study was conducted.
Article Synopsis
- Cardiac open-heart surgery can be risky for older people, especially if they have a condition called sarcopenia, which means they have less muscle mass.
- In a study analyzing 12 research papers, it was found that older patients with sarcopenia had a higher chance of dying after surgery and needed to stay in the hospital longer.
- By recognizing sarcopenia early, doctors can take better care of these patients and help them have safer surgeries.
Article Synopsis
- * A study comparing two methods of pudendal nerve block showed that adding dexamethasone to the anesthesia significantly reduced moderate to severe pain during the first dressing change and improved overall recovery quality.
- * The combination of ropivacaine and dexamethasone not only lowered pain levels but also decreased incidents of complications like postoperative urinary retention, indicating a potential advancement in pain management strategies post-surgery.
Article Synopsis
- The text indicates that there is a correction to the findings or content of the article identified by the DOI 10.1371/journal.pone.0278871.
- This correction may address errors or omissions that were present in the original publication.
- Corrections like this are important for maintaining the accuracy and integrity of scientific literature.
Article Synopsis
- Pudendal neuralgia is a painful condition affecting 5-26% of people and is treated through various methods, but drug therapy often provides limited relief.
- This study investigates the effectiveness and safety of pulsed radiofrequency therapy alone versus in combination with ganglion impar block in patients who haven't responded to other treatments.
- The trial will involve 84 participants, measuring pain and psychological outcomes while monitoring for side effects, with analysis focusing on differences between the treatment methods and various patient subgroups.
Article Synopsis
- This study examines adverse events (AEs) and adverse drug reactions (ADRs) linked to the antifibrotic drugs pirfenidone and nintedanib, used for treating idiopathic pulmonary fibrosis (IPF).
- Analysis involved data from over 90,000 reports in two major databases, highlighting that male patients and those over 65 are more likely to report AEs, with gastrointestinal issues being the most prevalent.
- The research identified novel ADR signals, such as hemiplegic migraine for pirfenidone and asthenia for nintedanib, emphasizing the importance of ongoing safety evaluations despite the drugs being mostly deemed safe according to label information.
Background: Splanchnic nerve neurolysis (SNN) is commonly used as an alternative pain control technique to celiac plexus neurolysis (CPN) in patients with distortion of anatomy, but the analgesic effect and relative risks of the 2 procedures remain controversial in general condition.
Objectives: The aim of this study was to evaluate the pain condition, safety, and symptom burden of SNN compared with CPN.
Study Design: A systematic review and meta-analysis of neurolysis therapy for intractable cancer-related abdominal pain.
Article Synopsis
- Mental disorders, influenced by various biological, psychological, and social factors, significantly contribute to global health issues, prompting this study to explore how essential life elements like smoking, sleep, and BMI affect conditions like major depressive disorder (MDD) and bipolar disorder (BD).
- The research utilized Mendelian randomization to link genetic traits from previous studies on smoking, sleep, and BMI to their potential causal effects on MDD and BD, involving extensive genetic instrument analysis and sensitivity checks for reliability.
- Results indicated that smoking, poor sleep, and high BMI are risk factors for MDD, while smoking and disrupted sleep also posed significant risks for BD, suggesting complex interactions among these factors, especially highlighting smoking's mediating role in sleep's effect
Purpose: Observe uninterrupted thrombolytic therapy via indwelling catheter for lower limb deep vein thrombosis.
Methods: We retrospectively studied data from 32 patients with lower extremity deep vein thrombosis who received comprehensive treatment, consisting of general treatment, inferior vena cava filter implantation, interventional thrombolysis, angioplasty, stenting, and post-operative monitoring.
Results: The efficacy and safety of the comprehensive treatment were observed for a follow-up period of 6-12 months.
Background: General anesthetics (eg, propofol and volatile anesthetics) enhance the slow-delta oscillations of the cortical electroencephalogram (EEG), which partly results from the enhancement of (γ-aminobutyric acid [GABA]) γ-aminobutyric acid-ergic (GABAergic) transmission. There is a GABAergic excitatory-inhibitory shift during postnatal development. Whether general anesthetics can enhance slow-delta oscillations in the immature brain has not yet been unequivocally determined.
View Article and Find Full Text PDFStudy on MEV90 of 0.5% ropivacaine for US-guided caudal epidural block in anorectal surgery.
Front Med (Lausanne)
January 2023
Background: Choosing the appropriate concentration and volume of anesthetics is critical for a successful nerve block. The current study aimed to determine the minimum effective volume (MEV) of 0.5% ropivacaine for US-guided CEB in 90% of patients (MEV90) undergoing anorectal surgery.
View Article and Find Full Text PDFBackground: Volatile anesthetics including sevoflurane and isoflurane enhance oscillations of cortical electroencephalogram (EEG), partly by their modulations on glutamate-mediated excitatory synaptic transmission. Expression of NMDA receptors is increased during neonatal development. However, how the development of NMDA receptors influences EEG under volatile anesthesia remains unclear.
View Article and Find Full Text PDFBackground: Conflicting outcomes have been reported for the i-gel™ and laryngeal mask airway (LMA) ProSeal™ in children and adults during general anesthesia. Randomized controlled trials (RCTs) that yielded wide contrast outcomes between i-gel™ and LMA ProSeal™ were included in this meta-analysis.
Methods: Two authors independently identified RCTs that compared i-gel™ with LMA ProSeal™ among patients receiving general anesthesia by performing searches in EMBASE, Cochrane, PubMed, and ScienceDirect.
Pulmonary fibrosis is a chronic progressive form of interstitial lung disease, characterized by the histopathological pattern of usual interstitial pneumonia. Apart from aberrant alterations of protein-coding genes, dysregulation of non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs (circRNAs), is crucial to the initiation and progression of pulmonary fibrosis. CircRNAs are single-stranded RNAs that form covalently closed loops without 5' caps and 3' tails.
View Article and Find Full Text PDFIntroduction: This study aimed to compare the efficacy between patient-controlled caudal epidural analgesia (PCCA) and patient-controlled intravenous analgesia (PCIA) after perianal surgery, to provide a feasible solution to postoperative pain.
Methods: This was a prospective, randomized controlled trial comprising 100 patients who underwent caudal epidural block on perianal surgery at Chengdu Shang Jin Nan Fu Hospital of West China Hospital at Sichuan University between April and August 2020. Patients were randomly divided into the PCCA and PCIA groups.
Ferroptosis is a unique and pervasive form of regulated cell death driven by iron-dependent phospholipid peroxidation. It results from disturbed cellular metabolism and imbalanced redox homeostasis and is regulated by various cellular metabolic pathways. Recent preclinical studies have revealed that ferroptosis may be an attractive therapeutic target in fibrotic diseases, such as liver fibrosis, pulmonary fibrosis, kidney fibrosis, and myocardial fibrosis.
View Article and Find Full Text PDFBackground: While emergency laparotomy has been associated with high rates of postoperative mortality and adverse events, preoperative systematic evaluation of patients may improve perioperative outcomes. However, due to the critical condition of the patient and the limited operation time, it is challenging to conduct a comprehensive evaluation. In recent years, sarcopenia is considered a health problem associated with an increased incidence of poor prognosis.
View Article and Find Full Text PDFBackground: Amniotic fluid embolism (AFE) is a rare disease that can lead to profound coagulopathy and hemorrhage, especially when combined with the laceration and bleeding of other organs. Intraoperative cell salvage (ICS) has been widely used for treating obstetric hemorrhage, but it remains unclear whether ICS can be used in the treatment of AFE.
Case Presentation: We report the case of a 27-year-old woman at 39 weeks' gestation who suddenly developed severe abdominal pain, convulsions, loss of consciousness, and decreased vital signs during labor.
Objective: Catheter-related bladder discomfort (CRBD) is a common complication of intraoperative urinary catheterization. Various studies have evaluated the efficacy of different interventions in postoperative CRBD. The present review was performed to assess the efficacy of these interventions.
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