Publications by authors named "Ru-yu Wang"
Article Synopsis
- Triple-negative breast cancer (TNBC) has high mortality due to its aggressive nature and spread, necessitating the search for effective treatments.
- A study identified aurovertin B (AVB) as a potent antimetastatic compound, significantly reducing metastasis in various TNBC cell lines and a mouse model.
- The research uncovered that AVB works by upregulating DUSP1 through the transcription factor ATF3, providing new insights into the mechanisms driving TNBC metastasis.
Ethnopharmacological Relevance: Ferroptosis, a recently identified non-apoptotic form of cell death reliant on iron, is distinguished by an escalation in lipid reactive oxygen species (ROS) that are iron-dependent. This phenomenon has a strong correlation with irregularities in iron metabolism and lipid peroxidation. Salvia miltiorrhiza Bunge (DS), a medicinal herb frequently utilized in China, is highly esteemed for its therapeutic effectiveness in enhancing blood circulation and ameliorating blood stasis, particularly during the treatment of cardiovascular diseases (CVDs).
View Article and Find Full Text PDFThe bamboo forest growth optimization (BFGO) algorithm combines the characteristics of the bamboo forest growth process with the optimization course of the algorithm. The algorithm performs well in dealing with optimization problems, but its exploitation ability is not outstanding. Therefore, a new heuristic algorithm named orthogonal learning quasi-affine transformation evolutionary bamboo forest growth optimization (OQBFGO) algorithm is proposed in this work.
View Article and Find Full Text PDFMicroRNA and circRNA Expression Analysis in a Zbtb1 Gene Knockout Monoclonal EL4 Cell Line.
Front Cell Infect Microbiol
July 2021
Zinc finger and BTB domain containing 1(Zbtb1) is a transcriptional suppressor protein, and a member of the mammalian Zbtb gene family. Previous studies have shown that Zbtb1 is essential for T-cell development. However, the role of Zbtb1 in T-cell lymphoma is undetermined.
View Article and Find Full Text PDFArticle Synopsis
- - Lactic acid bacteria (LAB), specifically LGG ATCC 53103, were found to enhance the diversity and abundance of intestinal microbiota in BALB/c mice, indicated by improved indices such as OTU and Shannon, while the Simpson index decreased.
- - LGG not only affected gut microbiota but also regulated the immune system by altering the distribution of various T lymphocytes and boosting the production of Th1 and Th2 cytokines, leading to a balanced immune response.
- - The study revealed that LGG treatment increased IL-17 expression and influenced the levels of regulatory T cells (Treg), suggesting a role in maintaining the balance between Th-17 and Treg cells in the immune system.
Objective: To explore operative effect of lumbar intervertebral disc herniation accompanying with lumbar instability.
Methods: Form June 2000 to June 2006, 46 patients of lumbar intervertebral disc herniation accompanying with lumbar instability were treated with decompression through posterior approach, diskectomy, spinal fusion and vertebral pedicle internal fixation. Including 33 males and 13 females,the age was from 37 to 68 years with an average of 48 years.