[Synthesis and bioactivity of substituted alpha-aminobenzylphosphonate].

Aim: To search for some substituted alpha-amino phosphonates as leading compounds with the vasodilator effects.

Methods: Target compounds were prepared from benzyl aldehyde, piperazine and diethyl phosphite using alcohol as solvent via Mannich-type reaction. In isolated rat aorta and in isolated guinea pig ileum, the vasodilator effects of compounds were investigated and evaluated whether they activated muscarine receptor.