Publications by authors named "Ru-Xia Han"
Background: Toxoplasma gondii is an important protozoan pathogen with medical and veterinary importance worldwide. Drugs currently used for treatment of toxoplasmosis are less effective and sometimes cause serious side effects. There is an urgent need for the development of more effective drugs with relatively low toxicity.
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- Synergistic photothermal immunotherapy is an emerging method for combating cancer, but creating a system that effectively suppresses tumor growth and prevents metastasis is challenging.
- The study develops a dual delivery system, CPG@Au NRs/m-R848, which effectively enhances anti-tumor responses by promoting dendritic cell maturation and converting M2 macrophages to the more aggressive M1 type.
- The treatment showed potential in reducing tumor growth in a mouse model by stimulating a CD8+ T cell immune response, indicating its effectiveness in tumor immunotherapy through improved immune cell activity and induction of immunogenic cell death.
Phenylketonuria (PKU) is a common disease associated with amino acid metabolism, and usually occurs in newborns. It can cause serious neurological diseases and even death. However, owing to inadequate-effective treatment, it can only be slowed by a low-phenylalanine (Phe) diet.
View Article and Find Full Text PDFThe prevalence of skin cancer is rising along with the rapid population aging in recent years. Traditional therapies, such as surgical treatment, radiotherapy, chemotherapy, photodynamic therapy, and immunotherapy, may accompany serious side effects, limiting their clinical benefits. According to the biological characteristics of skin cancer, we have already established two kinds of synergetic systems of photothermal therapy (microneedle) and chemotherapy, containing gold nanorods (GNR).
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