Association between the immune-inflammation indicators and osteoarthritis - NHANES 1999-2018.

Background: Investigate the link between systemic immune-inflammatory index (SII) and Systemic Immune Response Index (SIRI) with osteoarthritis (OA) using National Health and Nutrition Examination Survey (NHANES) data (1999-2018).

Methods: Extracted NHANES data (1999-2018) and selected a study population based on demographic, examination, and laboratory data. Calculated SII (platelet count ​× ​neutrophil count/lymphocyte count) and SIRI (neutrophil count ​× ​monocyte count/lymphocyte count).

Causal Relationships Between Blood Lipid Levels and Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Analysis.

Background: In preliminary research and literature review, we identified a potential link between chronic obstructive pulmonary disease (COPD) and lipid metabolism. Therefore, this study employed Mendelian randomization (MR) analysis to investigate the potential causal connection between blood lipids and COPD.

Materials And Methods: A genome-wide association study (GWAS) on COPD was conducted, encompassing a total of 112,583 European participants from the MRC-IEU.

Macroelements Intake in Chinese Adults - 10 PLADs, China, 2022-2023.

What Is Already Known About This Topic?: The Chinese Nutrition and Health Surveillance in 2015-2017 reported that among adults aged 18-59 years, the average daily intake was 328.3 mg of calcium, 251.8 mg of magnesium, 5,681.

Physical Activity and Sedentary Behavior Among Chinese Adults - 10 PLADs, China, 2022-2023.

What Is Already Known About This Topic?: The prevalence of insufficient physical activity (PA) among Chinese adults has shown an upward trend, reaching 22.3% in 2018. Leisure time PA (LTPA) constitutes a minimal proportion of total physical activity patterns.

Mesenchymal stem cells for osteoarthritis: Recent advances in related cell therapy.

Osteoarthritis (OA) is a degenerative joint disease that affects the entire joint and has been a huge burden on the health care system worldwide. Although traditional therapy and targeted cartilage cell therapy have made significant progress in the treatment of OA and cartilage regeneration, there are still many problems. Mesenchymal stem cells from various tissues are the most studied cell type and have been used in preclinical and clinical studies of OA, because they are more widely available, have a greater capacity for in expansion, and have anti-inflammatory and immunomodulatory properties compared to autologous chondrocytes.

Prevalence and Risk Factors of Lower Extremity Musculoskeletal Disorders Among Occupational Groups in Key Industries - China, 2018-2023.

What Is Already Known About This Topic?: Lower extremity musculoskeletal diseases (LE-MSDs) have emerged as a significant contributor to the global disease economic burden and worker absenteeism, becoming a global public health concern. However, the epidemic characteristics of LE-MSDs among occupational populations in China are unknown.

What Is Added By This Report?: This report finds that the LE-MSDs prevalence rate among key occupational groups in China is 17.

Altered brain functional connectivity in patients with tension-type headache.

Objective: To evaluate whether patients with tension-type headache (TTH) exhibit abnormal brain functional connectivity compared to healthy controls.

Background: TTH is one of the most prevalent headache disorders throughout the world. The present study delves into brain functional connectivity in patients with TTH to enhance the understanding of its underlying pathophysiology.

Steady state and transient absorption spectroscopy in metal halide perovskites.

Metal halide perovskites (MHPs) have emerged as the most promising materials due to superior optoelectronic properties and great applications spanning from photovoltaics to photonics. Absorption spectroscopy provides a broad and deep insight into the carrier dynamics of MHPs, and is a critical complement to fluorescence and scattering spectroscopy. However, absorption spectroscopy is often misunderstood or underestimated, being seen as UV-vis spectroscopy only, which can lead to various misinterpretations.

C3/C3aR Bridges Spinal Astrocyte-Microglia Crosstalk and Accelerates Neuroinflammation in Morphine-Tolerant Rats.

Aims: Communication within glial cells acts as a pivotal intermediary factor in modulating neuroimmune pathology. Meanwhile, an increasing awareness has emerged regarding the detrimental role of glial cells and neuroinflammation in morphine tolerance (MT). This study investigated the influence of crosstalk between astrocyte and microglia on the evolution of morphine tolerance.

Distribution Characteristics in Clinical Phenotype and Immunohistochemistry of STK11 Adnexal Tumors: Case Report and Narrative Synthesis.

adnexal tumors are recently named tumors of the female adnexal region, associated with Peutz-Jeghers syndrome (PJS). There is a lack of studies on the clinical phenotypes of PJS concerning the pathology and molecular characteristics of adnexal tumors. We searched for 781 relevant studies through PubMed and Web of Science, and preliminary statistical and grouping comparisons were made using the screened study data combined with our patient.

Foliar Spraying of Nanoselenium Improves the Nutritional Quality of Alfalfa by Recruiting Beneficial Phyllosphere Bacteria and Regulating the Distribution and Translocation of Selenium.

Nanoselenium shows potential trends in improving plant health and food quality. In this study, different concentrations of nanoselenium were sprayed on the leaves of alfalfa. Compared to the control, nanoselenium (100 mg·L) significantly increased SeMet and SeMeCys contents in the roots, stems, and leaves of alfalfa.

Regularly Arranged Heterogeneous Pores in Gas Separation Membranes Constructed by Cocrystallization of Porous Organic Molecules.

Integrating two or more materials to construct membranes with heterogeneous pore structures is an effective strategy for enhancing separation performance. Regularly arranging these heterogeneous pores can significantly optimize the combined effect of the introduced components. Porous Organic Cages (POCs), an emerging subclass of porous materials composed of discrete molecules, assemble to form interconnected pores and exhibit permanent porosity in the solid state.

Resurgence of common respiratory viruses and mycoplasma pneumoniae after ending the zero-COVID policy in Shanghai.

China has adhered to policies of zero-COVID for almost three years since the outbreak of COVID-19, which has remarkably affected the circulation of respiratory pathogens. However, China has begun to end the zero-COVID policies in late 2022. Here, we reported a resurgence of common respiratory viruses and Mycoplasma pneumoniae with unique epidemiological characteristics among children after ending the zero-COVID policy in Shanghai, China, 2023.

Developing novel Lin28 inhibitors by computer aided drug design.

Lin28 is a key regulator of cancer stem cell gene network that promotes therapy-resistant tumor progression in various tumors. However, no Lin28 inhibitor has been approved to treat cancer patients, urging exploration of novel compounds as candidates to be tested for clinical trials. In this contribution, we applied computer-aided drug design (CADD) in combination with quantitative biochemical and biological assays.

1.5D Chiral Perovskites Mediated by Hydrogen-Bonding Network with Remarkable Spin-Polarized Property.

In this study, we developed new chiral hybrid perovskites, (R/S-MBA)(GA)PbI, by incorporating achiral guanidinium (GA) and chiral R/S-methylbenzylammonium (R/S-MBA) into the perovskite framework. The resulting materials possess a distinctive structural configuration, positioned between 1D and 2D perovskites, which we describe as 1.5D.

Analysis of key lncRNA related to Parkinson's disease based on gene co-expression weight networks.

Objectives: To identify a key Long chain non-coding RNAs (lncRNAs) related to PD and provide a new perspective on the role of LncRNAs in Parkinson's disease (PD) pathophysiology.

Methods: Our study involved analyzing gene chips from the substantia nigra and white blood cells, both normal and PD-inclusive, in the Gene Expression Omnibus (GEO) database, utilizing a weighted gene co-expression network analysis (WGCNA). The technique of WGCNA facilitated the examination of differentially expressed genes (DEGs) in the substantia nigra and the white blood cells of individuals with PD.

HDAC and MEK inhibition synergistically suppresses HOXC6 and enhances PD-1 blockade efficacy in BRAF-mutant microsatellite stable colorectal cancer.

Background: B-Raf proto-oncogene, serine/threonine kinase (BRAF)-mutant microsatellite stable (MSS) colorectal cancer (CRC) constitutes a distinct CRC subgroup, traditionally perceived as minimally responsive to standard therapies. Recent clinical attempts, such as BRAF inhibitors (BRAFi) monotherapy and combining BRAFi with other inhibitors, have yielded unsatisfactory efficacy. This study aims to identify a novel therapeutic strategy for this challenging subgroup.

Investigating the molecular mechanisms of Jiangu Decoction in treating type 2 diabetic osteoporosis.

Ethnopharmacological Relevance: Type 2 diabetic osteoporosis (T2DOP) is a metabolic bone disease characterized by impaired bone structure and decreased bone strength in diabetic patients. Jiangu Decoction (JGD), a traditional Chinese poly-herbal formulation, has shown efficacy in mitigating osteoporosis (OP) and fractures caused by osteoporosis in diabetic patients in clinical trials. In addition, JGD has been proven to promote the proliferation of osteoblasts.

Comparison of vehicular emissions at different altitudes: Characteristics and policy implications.

Applying real-world driving emissions (RDE) data to machine learning, this study investigated vehicular emission characteristics and reduction strategies in Tianjin and Xining, two cities at different altitudes. Significant differences in CO₂ and particulate number (PN) emissions were observed, primarily due to altitude-induced changes in air pressure, affecting air resistance and combustion efficiency. Driving conditions and emission standards were identified as key factors influencing emissions, with road grade and air pressure playing crucial roles at high altitudes.

Bidirectional effect modifications of temperature and PM on myocardial infarction morbidity and mortality in Beijing, China from 2007 to 2021.

Background: Ambient temperatures and PM can trigger myocardial infarction (MI), while little is known about the complex interplay between these two factors on MI, especially morbidity.

Objectives: To investigate bidirectional effect modifications of temperature and PM on MI morbidity and mortality.

Methods: A time-stratified case-crossover study was conducted utilizing high-resolution data of temperature and PM, along with 498,077 MI cases from the citywide registry in Beijing, China from 2007 to 2021.

Multi-stage optimization framework for synergetic grey-green infrastructure in response to long-term climate variability based on shared socio-economic pathways.

Global climate change and rapid urbanization have increasingly intensified extreme rainfall events and surface runoff, posing significant challenges to urban hydrological security. Synergetic Grey-Green Infrastructure (SGGI) has been widely applied to enhance stormwater management in urban areas. However, current research primarily focused on optimizing and evaluating either grey infrastructure (GREI) or green infrastructure (GI) under single rainfall event, neglecting the non-stationary impacts of long-term climate change on infrastructure performance.

Molecular mechanisms of transcription factor KLF4-mediated immune infiltration influencing lung adenocarcinoma invasion.

Background: Lung adenocarcinoma (LUAD) is associated with an increasing incidence and mortality rate while existing treatment strategies continue to exhibit considerable limitation. Studies have demonstrated that upregulation of KLF4 gene inhibits LUAD progression, but its underlying mechanisms remain elusive. The present research explored roles and mechanisms of KLF4 and the NF-κB pathway in LUAD.

Albumin-seeking NIR dyes for high-sensitive imaging of glomerular filtration barrier breakdown.

The kidney, vital for metabolic balance, faces risks of severe diseases if dysfunctional. The glomerular filtration barrier (GFB), crucial for blood filtration, disrupts in conditions like diabetic nephropathy or nephritides, resulting in proteinuria or even renal failure. Monitoring GFB integrity is essential for early diagnosis or prognostic monitoring.