Publications by authors named "Ru-Ping Yan"
Objectives: To investigate the effect of glycopeptide-preferring polypeptide GalNAc transferase 1 (ppGalNAc T1) targeted RNA interference (RNAi) on the growth and migration of human bladder carcinoma EJ cells in vitro and in vivo.
Methods: DNA microarray assays were performed to determine ppGalNAc Ts(ppGalNAc T1-9) expression in human bladder cancer and normal bladder tissues. We transfected the EJ bladder cancer cell line with well-designed ppGalNAc T1 siRNA.
Article Synopsis
- The study establishes a nude mouse model to mimic human bladder cancer, focusing on the use of a human bladder cancer cell line, BIU-87, to evaluate new treatments like immunotoxin therapy.
- Researchers used MRI to monitor tumor growth weekly, with a high tumor establishment rate of 92.9% in the mice, showing promising results for future research.
- The model maintained key biological and immunological traits of the original human cells, making it a valuable tool for preclinical studies on intravesical cancer therapies.