Publications by authors named "Ru-Ping Pan"
Nat Commun
September 2024
Article Synopsis
- Beige fat activation shifts energy use to fatty acid oxidation after chronic cold exposure, involving a protein called ACSL1 located in mitochondria.
- Sortilin is an endosomal trafficking component that helps direct ACSL1 for degradation, affecting its levels in adipose tissues during beige fat activation.
- Lowering sortilin in fat cells raises mitochondrial ACSL1, boosts AMPK/PGC1α signaling, enhances beige fat activation, and may help combat obesity and insulin resistance linked to high-fat diets.
