En bloc resection and prosthesis implantation to treat malignant fibrous histiocytoma of the humerus.

Background: Malignant fibrous histiocytoma (MFH) of the bone is a rare tumor. Most studies comparing limb salvage and amputation have reported that limb salvage had no adverse effect on the long-term survival of patients. This study evaluates the oncological outcomes of limb salvage procedures that were used for 15 patients with MFH of the humerus.

Mosaicplasty associated with gene enhanced tissue engineering for the treatment of acute osteochondral defects in a goat model.

Objective: To compare single mosaicplasty, mosaicplasty associated with gene enhanced tissue engineering and mosaicplasty associated with the gels of non-gene transduced bone mesenchymal stem cells (BMSCs) in alginate for the treatment of acute osteochondral defects in a goat model.

Methods: The principle and methods of tissue engineering were used. BMSCs were separated and amplified in vitro, and human transforming growth factor-beta1 (hTGF-beta1) gene was transduced to the cells.