Gcn5- and Bre1-mediated Set2 degradation promotes chronological aging of Saccharomyces cerevisiae.

Loss of transcription-coupled histone H3 lysine 36 trimethylation (H3K36me3) contributes to shorter lifespans in eukaryotes. However, the molecular mechanism of the decline of H3K36me3 during aging remains poorly understood. Here, we report that the degradation of the methyltransferase Set2 is the cause of decreased H3K36me3 levels during chronological aging in budding yeast.

The relationship between calcium (water) density and age distribution in adult women with spectral CT: initial result compared to bone mineral density by dual-energy X-ray absorptiometry.

Background: Calcium (water) density (D) of gemstone spectral imaging by spectral computed tomography (CT) is a new method of evaluating bone structures.

Purpose: To investigate age-related change of D of a chosen lumbar vertebra in adult women with spectral CT and the correlation between the D and bone mineral density (BMD) of dual-energy X-ray absorptiometry (DXA).

Material And Methods: A total of 305 adult women underwent spectral CT, 127 of whom simultaneously underwent DXA.

Reduction of metal artifacts from unilateral hip arthroplasty on dual-energy CT with metal artifact reduction software.

Background The evaluation of hip arthroplasty is a challenge in computed tomography (CT). The virtual monochromatic spectral (VMS) images with metal artifact reduction software (MARs) in spectral CT can reduce the artifacts and improve the image quality. Purpose To evaluate the effects of VMS images and MARs for metal artifact reduction in patients with unilateral hip arthroplasty.

Virtual monochromatic spectral imaging for the evaluation of vertebral inconspicuous osteoblastic metastases from lung.

Background The diagnosis of inconspicuous osteoblastic metastases (OBMs) is a challenge in computed tomography (CT) images. The virtual monochromatic spectral (VMS) image of spectral CT is useful for the detection of the low-contrast lesions. Purpose To select the optimal monochromatic level for VMS images of spectral CT for detecting and diagnosing inconspicuous OBMs of the vertebra from lung cancer.

Metal artifact reduction using virtual monochromatic images for patients with pedicle screws implants on CT.

Purpose: To evaluate the effect of spectral CT for metal artifact reduction in patients with pedicle screw.

Methods: 45 patients with 119 pairs of pedicle screws underwent spectral CT examination. One set of conventional (140 kVp) polychromatic image and nine sets of virtual monochromatic images (60-140 keV) were obtained.

[The changes of funny currents in the ventricular myocytes of neonatal rats and adult rats].

Aim: To record funny currents (If) of ventricular myocytes and to analysize hyperpolarization-activated cation channel(HCN) expression in the rats of different ages.

Methods: Fresh ventricular myocytes were isolated from 3 days rats and adult rats.HCN expressions were measured by real-time quantitative polymerase chain reaction(real-time PCR).