Publications by authors named "Ru Ning Zhou"

Article Synopsis
  • - This study investigates gene-environment interactions related to Crohn's disease (CD) among the Chinese population, focusing on specific single nucleotide polymorphisms (SNPs) in T helper 17 (Th17) pathway genes.
  • - Researchers analyzed data from 159 CD patients and 316 healthy controls, finding that certain SNP alleles were less common in CD patients compared to controls, with notable interactions between these genes and environmental factors like breastfeeding and sun exposure impacting disease aspects.
  • - The findings enhance understanding of the genetic factors contributing to CD in Chinese populations and suggest that including these SNPs in predictive models could improve risk and outcome assessments for the disease.
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Oxidative stress aggravates renal fibrosis, a pathway involved in almost all forms of chronic kidney disease (CKD). However, the underlying mechanism involved in the pathogenesis of renal oxidative stress has not been completely elucidated. In this study, we explored the role and mechanism of hypochlorite-modified albumin (HOCl-alb) in mediating oxidative stress and fibrotic response in a remnant-kidney rat model.

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