Dual-Sensitive Carbohydrate-Based Nanosystem for Targeted Drug Delivery to Potentiate the Therapeutic Efficacy of Ulcerative Colitis.

Purpose: Conventional oral formulations for inflammatory bowel disease (IBD) treatment are less than satisfactory, due to the poor controllability of drug release and lack of specificity to the inflammation sites in the gastrointestinal (GI) tract. To overcome these limitations, we developed a multiple carbohydrate-based nanosystem with pH/ROS dual responsibility and charge-mediated targeting ability for IBD-specific drug delivery.

Methods: In view of the overproduction of ROS and overexpression of cationic proteins in the inflammatory colon, the designed nanosystem was composed of oxidation-sensitive cyclodextrin (OX-CD), chitosan (CS) and pectin (AHP).

Design and control of a self-adjusting outdoor landscape wall.

This paper designs an outdoor landscape wall, which is equipped with an electrical motor, a sunlight intensity sensor and a rain sensor. The plants in the landscape wall will be rotated indoors when the weather is bad. To the contrary, based on signals from the sunlight intensity sensor, the plants can be rotated outdoors to get suitable sunlight.

The Application Effect of Doctor-Nurse Collaborative and Hierarchical Management Combined with Nursing Risk Management in Nursing Management of Patients with Postpartum Hemorrhage.

Background: To study the application effect of doctor-nurse collaborative and hierarchical management combined with nursing risk management in nursing management of patients with postpartum hemorrhage.

Methods: Overall 200 patients with postpartum hemorrhage treated in (Guangzhou, China) from Mar 2018 to Mar 2019 were divided into the experimental group and the control group. The experimental group received the nursing model of doctor-nurse collaborative and hierarchical management combined with nursing risk management while the control group received nursing risk management to compare the satisfaction, medical record quality before and after nursing, incidence of nursing risk events and treatment effect between the two groups.

Production of liquid fuels from Kraft lignin over bimetallic Ni-Mo supported on ZIF-derived porous carbon catalyst.

Non-noble bimetallic NiMo supported on zeolitic imidazolate framework-derived porous carbon (NiMo@FDC) catalyst for lignin depolymerization has been successfully developed. The synergism between Ni and Mo species in NiMo@FDC catalyst could promote the catalytic cleavage of C-O linkages in Kraft lignin. At a low reaction temperature of 240 °C and under 4 MPa H, the lignin liquefaction yield was 98.

The effect of postpartum family visits on the promotion of breastfeeding and improvement of maternal and infant health.

Objective: The study was designed to explore the effect of postpartum family visits on the promotion of breastfeeding and the improvement of maternal and infant health.

Methods: A total of 200 cases of parturients who gave birth in our hospital from January 2019 to January 2020 were selected as the research participants. According to a randomized, double-blinded and controlled manner, they were divided into a study group (n=100, with postpartum family visits) and a control group (n=100, without postpartum family visits).

Development of Axially Chiral Styrene-Type Carboxylic Acid Ligands via Palladium-Catalyzed Asymmetric C-H Alkynylation.

A weakly coordinated carboxylate-directed palladium-catalyzed atroposelective C-H alkynylation method for the development of novel axially chiral styrene-type carboxylic acids is disclosed. This transformation exhibits good yields (up to 85%), excellent enantiocontrol (up to 99% ee), and mild conditions. Notably, the synthetic utility of the resulting alkynyl carboxylic acid derivatives was demonstrated by various derivatizations as well as their potential as chiral ligands in asymmetric C-H activations.

Nickel-catalyzed reductive monofluoroakylation of alkyl tosylate with bromofluoromethane to primary alkyl fluoride.

A nickel-catalysed direct terminal monofluoromethlyation between alkyl tosylates and a low-cost, industrial raw material bromofluoromethane has been developed. This transformation has demonstrated high efficiency, mild conditions, and good functional-group compatibility. The key to success of this transformation lies in the ligand and mild base selection, ensuring the generation of various terminal monofluormethylation products.

Diversity-Oriented Synthesis of Aliphatic Fluorides via Reductive C(sp )-C(sp ) Cross-Coupling Fluoroalkylation.

Monofluorinated alkyl compounds are of great importance in pharmaceuticals, agrochemicals and materials. Herein, we describe a direct nickel-catalyzed monofluoromethylation of unactivated alkyl halides using a low-cost industrial raw material, bromofluoromethane, by demonstrating a general and efficient reductive cross-coupling of two alkyl halides. Results with 1-bromo-1-fluoroalkane also demonstrate the viability of monofluoroalkylation, which further established the first example of reductive C(sp )-C(sp ) cross-coupling fluoroalkylation.

[Characteristics of volatile organic compounds (VOCs) emission from electronic products processing and manufacturing factory].

Based on the EPA method T0-11 and 14/15 for measurement of toxic organics in air samples, fast VOCs detector, Summa canister and DNPH absorbent were used to determine the VOCs concentrations and the compositions in the ambient air of the workshops for different processes as well as the emission concentration in the exhaust gas. In all processes that involved VOCs release, concentrations of total VOCs in the workshops were 0.1-0.