The morphologic changes induced by hormone and radiation therapy on prostate carcinoma.

The morphologic changes induced by hormone and radiation therapy were evaluated in prostate biopsy and prostatectomy specimens from patients with residual prostate carcinoma. The two therapeutic methods induce changes both in the nonmalignant and malignant residual prostatic tissue. Following hormone therapy, the nonmalignant prostatic tissue showed atrophy of prostatic acini associated with fibrosis, basal cell hyperplasia, degenerative changes of the secretory epithelial cells, and a marked decrease of high-grade intraepithelial neoplasia (HGPIN).

Molecular mechanisms in hormone-resistant prostate cancer.

Prostate cancer is the most common malignancy in males. Despite the efforts for an early diagnosis, approximately one third of the cases are diagnosed in advanced clinical stages. Prostatic cancer, as the function of normal prostate is dependent upon androgens.

[Is partial cystectomy a justified intervention in the treatment of bladder tumors?].

The authors present their experience of 122 partial cystectomy cases made on a number of 288 vesical tumors in our clinic, during 5 years (1986-1991) from which 23 are superficial tumors and 99 are infiltrative ones. The treatment of vesical tumors can be done in many ways; this partial cystectomy must be completed with an other therapeutic method: irradiation on chemotherapy in conformity with the anatomo-pathological form, the steady and tumoral grading.

[The therapeutic approach in superficial epithelial tumors of the bladder. Apropos 98 cases].

Between 1985 and 1990, superficial epithelial tumors of gallbladder were found in 98 patients. Peculiar aspects such as age, sex, symptoms, clinical and laboratory diagnosis, surgical treatment, additional interventions, postoperative treatment, anatomo-pathological examination, pTNM classification and tumoral grading, postoperative recurrences, occurring after the primary and adjuvant treatment, were analysed. After some general comments, the authors point out that in their experience the lowest rate of postoperative recurrences was obtained by a multimodal treatment, that is surgery and vesical instillations with cytostatics or B.

[Tumors of the upper urinary tract. Apropos 35 cases].

Thirty-five cases of upper urinary tract tumors treated by the authors in an interval of 10 years (1979-1988) are presented. After a detailed analysis of the cases some general considerations on the anatomopathologic forms of upper urinary tract tumors, stage classification, symptoms and clinical and laboratory diagnosis, therapeutical indications are made.

Morphometry in evaluating large cell malignant lymphomas in lymph node biopsies.

The values of some morphometric cell parameters were analysed in 12 cases of large cell non-Hodgkin's lymphoma (centroblastic and immunoblastic lymphoma and histiocytic sarcomas) in order to test the utility of the morphometric method as an additional element to the histologic diagnosis and to its further accuracy. The nuclear and nucleolar area, the number of nucleoli per nuclear cross section and the nucleus to nucleolus ratio were investigated. The morphometric data were obtained on histograms using the Giemsa stained sections.