Metformin in nonalcoholic steatohepatitis: a randomized controlled trial.

BACKGROUNDN onalcoholic steatohepatitis (NASH) is a common liver disease that can progress to cirrhosis or hepatocellular carcinoma. It is estimated that up to 3% of the Iranian population have this condition. Although the pathogenesis of NASH is incompletely understood, there is significant evidence pointing to the importance of insulin resistance.

Overnight dexamethasone suppression test in the diagnosis of Cushing's disease.

Realizing the cause of Cushing's syndrome (CS) is one of the most challenging processes in clinical endocrinology. The long high dose dexamethasone suppression test (standard test) is costly and need an extended inpatient stay. In this study we want to show the clinical utility of the overnight 8 mg dexamethasone suppression test (DST) for differential diagnosis of CS in a referral center.

Liver histology changes in nonalcoholic steatohepatitis after one year of treatment with probucol.

Background: Probucol, a lipid-lowering agent with antioxidant effects, is effective in normalizing liver enzymes in patients with nonalcoholic steatohepatitis (NASH). We studied changes in the liver histology of patients with NASH after use of probucol for one year.

Methods: Ten patients with biopsy-proven NASH were included.