Publications by authors named "Rozaliya Tsikandelova"
Article Synopsis
- Biallelic mutations in the DRAM2 gene cause a form of vision loss called CORD21, which usually shows up between ages 30 and 60.
- Researchers studied retinal organoids and retinal pigment epithelium (RPE) cells from patients with CORD21 to understand the gene's role in retinal degeneration.
- They discovered that DRAM2 is involved in lipid metabolism, lysosomal function, and cellular processes, indicating its importance for the health of photoreceptors and RPE cells.
Polymeric nanoparticles have been introduced as a delivery vehicle for active compounds in a broad range of medical applications due to their biocompatibility, stability, controlled release of active compounds, and reduced toxicity. The oral route is the most used approach for delivery of biologics to the body. The homeostasis and function of oral cavity tissues are dependent on the activity of stem cells.
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- FGF8 is a special protein that helps tooth development by guiding tooth cells to where teeth grow.
- Researchers tested how FGF8 can help adult tooth cells heal and grow stronger.
- The study found that FGF8 boosts the growth and healing of tooth cells and may help them do their job better in making teeth.
Objective: Platelet-derived growth factor-BB (PDGF-BB) is one of the most abundant growth factors in platelet derived products and has been shown to stimulate regeneration after tissue injury. There is a population of mesenchymal stem cells (MSC) in human periodontal ligament (PDL) which can contribute to tissue regeneration under appropriate conditions.
Design: PDL cells were isolated and characterized using stem cell and differentiation markers via immunofluorescence and flow cytometry and then cultured in vitro and treated with different concentrations of PDGF-BB.