Publications by authors named "Roza Yagudina"
The objective of this study is to develop a universally applicable approach for establishing the optimal dose range for the irradiation of plant and animal products. The approach involves the use of the optimization function for establishing the optimal irradiation dose range for each category of plant and animal product to maximize the suppression of targeted pathogens while preserving the surrounding molecules and biological structures. The proposed function implies that pathogens found in the product can be efficiently suppressed provided that irradiation is performed with the following criteria in mind: a high irradiation dose uniformity, a high probability of irradiation hitting pathogens and controlled heterogeneity of radiobiological sensitivity of pathogens.
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- - The study explores how the compound Ac-Lys-Lys-Lys-NH (Ac-KKK-NH) binds to the Na1.8 channel, which plays a key role in encoding pain signals in the peripheral nervous system, using both experimental and theoretical techniques.
- - Experimental results show that when Ac-KKK-NH is applied at a concentration of 100 nM, it significantly reduces the effective charge of the Na1.8 channel's activation gating, and it exhibits strong analgesic effects in pain tests conducted in live animals.
- - Conformational analysis reveals that the distances between positively charged groups in Ac-KKK-NH are 11-12 Å, and docking studies identify its binding site on the voltage-sensing
Article Synopsis
- Phenylketonuria (PKU) is a genetic disorder that requires individuals to follow a strict low-phenylalanine diet for life to avoid serious neurological issues, but adhering to this diet can be difficult for patients and their families.
- A systematic review analyzed 49 studies to identify the various factors affecting adherence to this diet, categorizing them into family-related, patient-specific, environmental, and therapy-related factors.
- The review stresses the need for a comprehensive approach to support PKU patients, emphasizing that future research should focus on producing high-quality longitudinal and experimental studies for better insights.
Purpose: Stimulating cost reduction of pharmaceutical companies to optimize the structure of distribution of patients by the level of treatment costs in various programs.
Patients And Methods: In this article, we rise up the issues of pharmacoeconomic modeling related to the description of the patient flows in the pharmacoeconomic model and methods to determining the course dose of drugs under the restriction of integer computations. We established two possible ways of distributing patients through treatment regimens in pharmacoeconomic models, also analyzed the effects of simultaneous and uniform entry of patients into the model.
Objectives: The objective of this study is to cover the ways of solving the problem of understanding the results of two key methods of pharmacoeconomic analysis - budget impact and cost-effectiveness. It is important to note that pharmacoeconomic assessment based on this evidence often has controversial character. The results of one type of analysis can characterize assessed health technology favorably, and the results of other critically.
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