Publications by authors named "Roza I Yagudina"
Article Synopsis
- - The study explores how the compound Ac-Lys-Lys-Lys-NH (Ac-KKK-NH) binds to the Na1.8 channel, which plays a key role in encoding pain signals in the peripheral nervous system, using both experimental and theoretical techniques.
- - Experimental results show that when Ac-KKK-NH is applied at a concentration of 100 nM, it significantly reduces the effective charge of the Na1.8 channel's activation gating, and it exhibits strong analgesic effects in pain tests conducted in live animals.
- - Conformational analysis reveals that the distances between positively charged groups in Ac-KKK-NH are 11-12 Å, and docking studies identify its binding site on the voltage-sensing
Objectives: The objective of this study is to cover the ways of solving the problem of understanding the results of two key methods of pharmacoeconomic analysis - budget impact and cost-effectiveness. It is important to note that pharmacoeconomic assessment based on this evidence often has controversial character. The results of one type of analysis can characterize assessed health technology favorably, and the results of other critically.
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