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Peritoneal carcinosis is considered to be a lethal disease with a very poor prognosis, however cytoreducticve surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) could represent a significant step forward in the therapy of peritoneal cranosis. In contrast to traditional surgical procedures and intravenous chemotherapy, which are moderately effective, CRS and HIPEC are new, personalised interventions, which can extend the lifespan of the patients in the majority of the cases. Moreover, there is a possibility to carry out definitive, curative therapy in a well-selected group of cases.