Publications by authors named "Roza A Izmailyan"
Patterns of alveolar macrophage activation upon attenuated and virulent African swine fever viruses in vitro.
Comp Immunol Microbiol Infect Dis
October 2020
Article Synopsis
- The study examined how two strains of African swine fever (ASF) viruses affect the activation of porcine alveolar macrophages (AM), noting differences in immune response.
- Cells infected with the virulent ASFV-Georgia2007 showed unique M1 polarization and changes in morphology, resulting in lower synthesis of certain interferons compared to those infected with the attenuated strain ASFV-BA71V.
- The findings suggest that the more virulent ASFV-Georgia2007 reduces the antiviral response of AM, indicating that the evolutionary decrease of ASFV virulence is linked to changes in host immune system regulation.
This article describes a simple method of measuring the number of viral genomes within viral factories. For this purpose, we use three DNA viruses replicating in the cytoplasm of the infected cells: wild-type African swine fever virus (ASFV)-Georgia 2007, culture-adapted type ASFV-BA71V, and Vaccinia virus (VV). The measurements are conducted in three steps.
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