Predictors of breakthrough clinically significant cytomegalovirus infection during letermovir prophylaxis in high-risk hematopoietic cell transplant recipients.

Letermovir prophylaxis in allogeneic hematopoietic cell transplant recipients significantly reduces the incidence of clinically significant cytomegalovirus infection. However, breakthrough infections still occur despite adequate prophylaxis. In the present retrospective cohort study, we identified clinically relevant predictive factors for clinically significant CMV breakthrough infection during letermovir prophylaxis.

Making Learning Fun: Gaming in Radiology Education.

With continued technologic advances, it is not surprising that gaming techniques are increasingly being used in radiology residency programs. This comprehensive review on gaming in radiology education offers insight into the importance of gaming, types of games and principles utilized in gaming, as well as applications that are inherent in artificial intelligence and continued medical education. The advantages and disadvantages of gaming will be considered, as well as barriers to successful adoption of gaming.

Preserving and perfusing the allograft pancreas: Past, present, and future.

The concept of organ preservation by perfusion dates back to the mid-19th century. Innovations since then have included temperature regulation, perfusion fluid composition and various pumping systems. Advances made in liver, heart and kidney machine preservation are now contributing to increased graft utilisation, assessment of graft viability and potentially improved graft survival.

DaT's Awesome: Hawai'i's First Dopamine Transporter (DaT) Nuclear Medicine Study.

Parkinsonian Syndromes are difficult to accurately diagnose and distinguish from other neurological processes such as essential tremor. Until now, physical exam and clinical presentation have been the gold standard for diagnosis (bradykinesia, tremor, rigidity, and postural instability).1 However, this leads to over- or under diagnosis and improper treatment due to variability in presentation and symptoms.

The rise and potential fall of pancreas transplantation.

Background: The aim of this review is to bring pancreatic transplantation out of the specialist realm, informing practitioners about this important procedure, so that they feel better equipped to refer suitable patients for transplantation and manage, counsel and support when encountering them within their own speciality.

Sources Of Data: Narrative review conducted in May 2017. OVID interface searching EMBASE and MEDLINE databases, using Timeframe: Inception to June 1, 2017.

The value of ultrasonography in the diagnosis of appendicitis.

Introduction: Ultrasonography is a commonly used investigation in the UK for patients with right iliac fossa pain where the diagnosis of appendicitis is unclear. The published sensitivity and specificity of ultrasonography is higher than the results observed by clinicians in every day practice. The aim of this study was to elucidate the real-world value of ultrasonography in the diagnosis of appendicitis, and its impact on negative appendicectomy rates (NAR).

Postcoital Hemorrhage of a Recurrent Seminal Vesicle Cyst Requiring Embolization.

Herein is a case of a 23-year-old man with recurrence of a seminal vesicle cyst after percutaneous drainage and laparoscopic excision complicated by hemorrhage requiring embolization. He presented to the emergency department for pain after ejaculation. Computed tomographic scan of his pelvis revealed extravasation of contrast near his cyst and pelvic fluid collection suspicious for a hematoma.

Femoroacetabular impingement: A classic case of cam-type impingement in a 21-year-old soldier.

We describe a case of femoroacetabular impingement (FAI) in a 21-year-old male U.S. Army Private.

Melanoma in buckinghamshire: data from the inception of the skin cancer multidisciplinary team.

Background. Melanoma incidence is increasing faster than any other cancer in the UK. The introduction of specialist skin cancer multidisciplinary teams intends to improve the provision of care to patients suffering from melanoma.

An atypical symptomatic discoid lateral meniscus in a toddler.

Meniscal tears and meniscal instability are rare complications of a discoid lateral meniscus in a very young child. We report a case of a 32-month-old male who presented with a limp and limited extension of his right knee. Magnetic resonance and sonographic images demonstrated a discoid meniscus with a posterior horn tear and unstable anterior horn, confirmed by arthroscopy.

Hypertrophic Pulmonary Osteoarthropathy: A Case Report.

A 42-year-old male presented to the emergency department with difficulty breathing and body pain particularly in his bilateral lower extremities. A workup was done and he was diagnosed with sarcomatoid carcinoma of the lung. Bone scintigraphy was performed and hypertrophic pulmonary osteoarthropathy was diagnosed to be the source of the pain.

Critical assessment of the anterolateral thigh flap donor site.

Background: The free anterolateral thigh flap (ALT) is now used as a 'workhorse flap'. The donor site morbidity is thought to be minimal, although most evidence derives from questionnaire-based studies rather than rigorous objective clinical assessment. In particular, robust quantitative data on thigh sensibility and quadriceps function is lacking.

Preparation of silica stabilized Tobacco mosaic virus templates for the production of metal and layered nanoparticles.

The use of biological molecules as templates for the production of metal nanoparticles and wires is often limited by the stability of the bio-template and its affinity for nucleating metal deposition. In this study, Tobacco mosaic virus (TMV) was used as a model bio-template to investigate the use of silica coatings as a means to both enhance template stability and increase its affinity for metal ions. Results indicate that the unmodified TMV particle can function as a template for the growth of thin (<1 nm) silica layers.

Self-assembly of virus-structured high surface area nanomaterials and their application as battery electrodes.

High area nickel and cobalt surfaces were assembled using modified Tobacco mosaic virus (TMV) templates. Rod-shaped TMV templates (300 x 18 nm) engineered to encode unique cysteine residues were self-assembled onto gold patterned surfaces in a vertically oriented fashion, producing a >10-fold increase in surface area. Electroless deposition of ionic metals onto surface-assembled virus templates produced uniform metal coatings up to 40 nm in thickness.

Deposition of platinum clusters on surface-modified Tobacco mosaic virus.

Nanoscaled Pt conductors were prepared from genetically engineered Tobacco mosaic virus (TMV) templates through Pt cluster deposition on the outer surface of the TMV. Pt clusters were synthesized and deposited on the engineered TMV with surface-exposed cysteine via the in situ mineralization of hexachloroplatinate anions. This deposition was driven by the specific binding between thiols and the solid metal clusters.

Characterization of silica-coated tobacco mosaic virus.

The deposition of silica on the surface of tobacco mosaic virus (TMV) is achieved at a higher pH (>7) as a means to enhance its usefulness as a template for the synthesis of nanostructures. Electron energy loss spectroscopy definitively shows the presence of a silica shell on the surface of the TMV while small angle X-ray scattering differentiates successfully between silica-coated TMV and silica particles in the presence of uncoated TMV. Importantly, coating reactions done in a 50% w/v methanol/water solution produce smaller silica nanostructures during the condensation of the hydrolysis intermediates, possibly aiding in obtaining uniform coating.

Improved metal cluster deposition on a genetically engineered tobacco mosaic virus template.

Improved depositions of various metal clusters onto a biomolecular template were achieved using a genetically engineered tobacco mosaic virus (TMV). Wild-type TMV was genetically altered to display multiple solid metal binding sites through the insertion of two cysteine residues within the amino-terminus of the virus coat protein. Gold, silver, and palladium clusters synthesized through in situ chemical reductions could be readily deposited onto the genetically modified template via the exposed cysteine-derived thiol groups.