Number agreement processing in adolescents with and without developmental language disorder (DLD): evidence from event-related brain potentials.

In morphologically richer languages, including French, one must learn the specific properties of number agreement in order to understand the language, and this learning process continues into adolescence. This study examined similarities and differences between French-speaking adolescents with and without developmental language disorder (DLD) when processing number agreement, and investigated how morpho-syntactic regularity affected language processing. Using event-related potentials (ERP) and only grammatical sentences with audio-visual mismatches, we studied ERP correlates to three types of number agreement: (1) regular determiner agreement in noun phrases, (2) regular subject-verb plural liaison, and (3) irregular subject-verb agreement.

Identifying Linguistic Markers of French-Speaking Teenagers With Developmental Language Disorder: Which Tasks Matter?

Purpose: This research aimed to identify reliable tasks discriminating French-speaking adolescents with developmental language disorder (DLD) from their peers with typical language (TL) and to assess which linguistic domains represent areas of particular weakness in DLD. Unlike English, morphosyntax has not been identified as a special area of weakness when compared with lexicosemantics in French preschoolers with DLD. Since there is evidence that subject-verb number agreement is consolidated in later childhood, one might expect morphosyntax to be a particular weakness and marker of French DLD only in (pre)adolescence.

The Multilingual Picture Database.

The growing interdisciplinary research field of psycholinguistics is in constant need of new and up-to-date tools which will allow researchers to answer complex questions, but also expand on languages other than English, which dominates the field. One type of such tools are picture datasets which provide naming norms for everyday objects. However, existing databases tend to be small in terms of the number of items they include, and have also been normed in a limited number of languages, despite the recent boom in multilingualism research.

Optimal surveillance strategies for patients with stage 1 cutaneous melanoma post primary tumour excision: three systematic reviews and an economic model.

Background: Malignant melanoma is the fifth most common cancer in the UK, with rates continuing to rise, resulting in considerable burden to patients and the NHS.

Objectives: The objectives were to evaluate the effectiveness and cost-effectiveness of current and alternative follow-up strategies for stage IA and IB melanoma.

Review Methods: Three systematic reviews were conducted.

Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy due to age-related macular degeneration.

Background: Age-related macular degeneration (AMD) is a highly prevalent condition in an ever-increasing elderly population. Although insidious in the early stages, advanced AMD (neovascular and atrophic forms) can cause significant visual disability and economic burden on health systems worldwide. The most common form, geographic atrophy, has no effective treatment to date, whereas neovascular AMD can be treated with intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections.

Incidence of sudden cardiac death in the young: a systematic review.

Objective: To summarise studies describing incidence of sudden cardiac death in a general population of young individuals to inform screening policy.

Design: Systematic review.

Data Sources: Database searches of MEDLINE, EMBASE and the Cochrane library (all inception to current) on 29 April 2019 (updated 16 November 2019), and forward/backward citation tracking of eligible studies.

Corrigendum: Eliciting ERP Components for Morphosyntactic Agreement Mismatches in Perfectly Grammatical Sentences.

[This corrects the article DOI: 10.3389/fpsyg.2019.

Verbing nouns and nouning verbs: Using a balanced design provides ERP evidence against "syntax-first" approaches to sentence processing.

In this event-related potential (ERP) study we reevaluate syntax-first approaches to sentence processing by implementing a novel paradigm in French that includes correct sentences, pure syntactic category violations, lexical-semantic anomalies, and combined anomalies. Our balanced design systematically controlled for target word (noun vs. verb) and the context immediately preceding it.

Growing Random Forests reveals that exposure and proficiency best account for individual variability in L2 (and L1) brain potentials for syntax and semantics.

Late second language (L2) learners report difficulties in specific linguistic areas such as syntactic processing, presumably because brain plasticity declines with age (following the critical period hypothesis). While there is also evidence that L2 learners can achieve native-like online-processing with sufficient proficiency (following the convergence hypothesis), considering multiple mediating factors and their impact on language processing has proven challenging. We recorded EEG while native (n = 36) and L2-speakers of French (n = 40) read sentences that were either well-formed or contained a syntactic-category error.

A Systematic Review of Economic Evaluations Assessing the Cost-Effectiveness of Licensed Drugs Used for Previously Treated Epidermal Growth Factor Receptor (EGFR) and Anaplastic Lymphoma Kinase (ALK) Negative Advanced/Metastatic Non-Small Cell Lung Cancer.

Background: Non-small cell lung cancer (NSCLC) is one of the most commonly diagnosed cancers. There are many published studies of cost-effectiveness analyses of licensed treatments, but no study has compared these studies or their approaches simultaneously.

Objective: To investigate the methodology used in published economic analyses of licensed interventions for previously treated advanced/metastatic NSCLC in patients without anaplastic lymphoma kinase or epidermal growth factor receptor expression.

Eliciting ERP Components for Morphosyntactic Agreement Mismatches in Perfectly Grammatical Sentences.

The present event-related brain potential (ERP) study investigates mechanisms underlying the processing of morphosyntactic information during real-time auditory sentence comprehension in French. Employing an auditory-visual sentence-picture matching paradigm, we investigated two types of anomalies using entirely grammatical auditory stimuli: (i) semantic mismatches between visually presented actions and spoken verbs, and (ii) number mismatches between visually presented agents and corresponding morphosyntactic number markers in the spoken sentences (determiners, pronouns in liaison contexts, and verb-final "inflection"). We varied the type and amount of number cues available in each sentence using two manipulations.

Comparative survival benefit of currently licensed second or third line treatments for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) negative advanced or metastatic non-small cell lung cancer: a systematic review and secondary analysis of trials.

Background: A review of therapies for advanced cancers licenced by the EMA between 2009 and 2013 concluded that for more than half of these drugs there was little evidence of overall survival or quality of life benefit. Recent years have witnessed a growing number of licensed second-line pharmacotherapies for advanced/metastatic non-small cell lung cancer (NSCLC). With the aim of gauging patient survival benefit, we conducted a systematic review of randomised controlled trials (RCT) and compared survival outcomes from available licensed treatments for patients with advanced/metastatic NSCLC.

Meniscal allograft transplantation after meniscectomy: clinical effectiveness and cost-effectiveness.

Purpose: To assess the clinical effectiveness and cost-effectiveness of meniscal allograft transplantation (MAT) after meniscal injury and subsequent meniscectomy.

Methods: Systematic review of clinical effectiveness and cost-effectiveness analysis.

Results: There is considerable evidence from observational studies, of improvement in symptoms after meniscal allograft transplantation, but we found only one small pilot trial with a randomised comparison with a control group that received non-surgical care.

Allografts in reconstruction of the posterior cruciate ligament: a health economics perspective.

Purpose: To review the relative cost-effectiveness of allografts and autografts in reconstruction of the posterior cruciate ligament.

Methods: Systematic review and cost-effectiveness analysis.

Results: The available evidence does not show any significant difference in clinical effectiveness between autografts and allografts.

Autograft or allograft for reconstruction of anterior cruciate ligament: a health economics perspective.

Purpose: To assess the clinical and cost-effectiveness of allografts versus autografts in the reconstruction of anterior cruciate ligaments.

Methods: Systematic review of comparative clinical effectiveness and cost-effectiveness analysis.

Results: Both autograft and allograft reconstruction are highly effective.

The cost-effectiveness of osteochondral allograft transplantation in the knee.

Purpose: Osteochondral allografts (OCA) consist of a layer of hyaline cartilage and a layer of underlying bone. They are used to repair combined defects of articular cartilage and bone. Such defects often occur in people far too young to have knee arthroplasty, for whom the main alternative to OCA is conservative symptomatic care, which will not prevent development of osteoarthritis.

Improving Uptake of Postnatal Checking of Blood Glucose in Women Who Had Gestational Diabetes Mellitus in Universal Healthcare Settings: A Systematic Review.

The aim of this systematic review is to look at the barriers to uptake and interventions to improve uptake of postnatal screening in women who have had gestational diabetes mellitus (GDM). Increasing postnatal screening rates could lead to timely interventions that could reduce the incidence of type 2 diabetes mellitus (T2DM), the associated long-term health complications, and the financial burden of T2DM. A systematic review of the literature was undertaken.

Autologous Chondrocyte Implantation with Chondrosphere for Treating Articular Cartilage Defects in the Knee: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.

Chondrosphere (Spherox) is a form of autologous chondrocyte implantation (ACI). It is licensed for repair of symptomatic articular cartilage defects of the femoral condyle and the patella of the knee with defect sizes up to 10 cm in adults. In a single technology appraisal (STA) [TA508] undertaken by the National Institute of Health and Care Excellence (NICE), Warwick Evidence was the Evidence Review Group (ERG) invited to independently review the evidence submitted by the manufacturer, Co.

Comparative efficacy and safety of licensed treatments for previously treated non-small cell lung cancer: A systematic review and network meta-analysis.

Purpose: This systematic review with network meta-analysis compared the efficacy and safety of currently licensed second-line treatments in patients with late stage non-small cell lung cancer (NSCLC).

Methods: Randomised controlled trials (RCTs) of participants with advanced/metastatic NSCLC receiving second/third line treatments were screened. We searched electronic databases (MEDLINE; EMBASE; Web of Science) from January, 2000 to July, 2017.

Treatments for dry age-related macular degeneration and Stargardt disease: a systematic review.

Background: Age-related macular degeneration (AMD) is the leading cause of visual loss in older people. Advanced AMD takes two forms, neovascular (wet) and atrophic (dry). Stargardt disease (STGD) is the commonest form of inherited macular dystrophy.

Ixazomib for Relapsed or Refractory Multiple Myeloma: Review from an Evidence Review Group on a NICE Single Technology Appraisal.

Ixazomib is an oral proteasome inhibitor used in combination with lenalidomide plus dexamethasone (IXA-LEN-DEX) and licensed for relapsed or refractory multiple myeloma. As part of a single technology appraisal (ID807) undertaken by the National Institute of Health and Care Excellence, the Evidence Review Group, Warwick Evidence was invited to independently review the evidence submitted by the manufacturer of ixazomib, Takeda UK Ltd. The main source of clinical effectiveness data about IXA-LEN-DEX came from the Tourmaline-MM1 randomized controlled trial in which 771 patients with relapsed or refractory multiple myeloma received either IXA-LEN-DEX or placebo-LEN-DEX as their second-, third-, or fourth-line treatment.

Multiplex tests to identify gastrointestinal bacteria, viruses and parasites in people with suspected infectious gastroenteritis: a systematic review and economic analysis.

Background: Gastroenteritis is a common, transient disorder usually caused by infection and characterised by the acute onset of diarrhoea. Multiplex gastrointestinal pathogen panel (GPP) tests simultaneously identify common bacterial, viral and parasitic pathogens using molecular testing. By providing test results more rapidly than conventional testing methods, GPP tests might positively influence the treatment and management of patients presenting in hospital or in the community.

Insensitivity to verb conjugation patterns in French children with SLI.

Specific language impairment (SLI) is characterised by persistent difficulties that affect language abilities in otherwise normally developing children (Leonard, 2014). It remains challenging to identify young children affected by SLI in French. We tested oral production of the passé composé tense in 19 children in kindergarten and first grade with SLI aged from 5;6 to 7;4 years.

The priming of priming: Evidence that the N400 reflects context-dependent post-retrieval word integration in working memory.

Which cognitive processes are reflected by the N400 in ERPs is still controversial. Various recent articles (Lau et al., 2008; Brouwer et al.