Publications by authors named "Roy Schwartz"
Objective: To identify genetic determinants specific to reticular pseudodrusen (RPD) compared with drusen.
Design: Genome-wide association study (GWAS) SUBJECTS: Participants with RPD, drusen, and controls from the UK Biobank (UKBB), a large, multisite, community-based cohort.
Methods: A deep learning framework analyzed 169,370 optical coherence tomography (OCT) volumes to identify cases and controls within the UKBB.
Purpose: To evaluate the impact of pegcetacoplan on its ability to slow the loss of visual function using microperimetry endpoints in eyes with geographic atrophy secondary to age-related macular degeneration (AMD).
Design: Post hoc analysis of phase 3 randomized controlled trial data.
Methods: Utilizing data from the OAKS study, which evaluated pegcetacoplan monthly (PM) or every other month (PEOM) vs sham for the treatment of GA secondary to AMD, microperimetry endpoints were assessed at baseline and every 6 months until 24 months, using a 10-2 grid composed of 68 points with a 4-2 threshold strategy.
Article Synopsis
- Reticular pseudodrusen (RPD) are a key factor in vision loss related to age-related macular degeneration (AMD), making their detection essential for effective clinical management.
- Researchers created a deep learning model that segments RPD from a dataset of 9,800 optical coherence tomography scans, achieving better agreement with retinal specialists compared to their own consensus.
- The model demonstrated high performance in detecting RPD across multiple test datasets, matching the accuracy of experienced specialists, and is now publicly accessible for use.
Purpose: To describe the occurrence of bilateral outer retinal columnar abnormalities, nonvasogenic cystoid macular edema, and drusen in the context of dense deposit disease.
Methods: Case report.
Patient: An 18-year-old girl with dense deposit disease was referred to our specialist center for diagnosis and management with findings consistent with bilateral nonvasogenic cystoid macular edema and drusen.
Purpose: The purpose of this study was to develop and validate a deep learning (DL) framework for the detection and quantification of reticular pseudodrusen (RPD) and drusen on optical coherence tomography (OCT) scans.
Methods: A DL framework was developed consisting of a classification model and an out-of-distribution (OOD) detection model for the identification of ungradable scans; a classification model to identify scans with drusen or RPD; and an image segmentation model to independently segment lesions as RPD or drusen. Data were obtained from 1284 participants in the UK Biobank (UKBB) with a self-reported diagnosis of age-related macular degeneration (AMD) and 250 UKBB controls.
Aims: To analyse the prevalence of visual impairment (VI), compare it to certification of visual impairment (CVI) and analyse VI associations in patients with diabetic retinopathy (DR).
Methods: Retrospective cohort study, which included 8007 patients with DR referred from the English diabetic eye screening programme to a tertiary referral eye hospital. Main outcome measure was VI, defined as vision in the best eye of <6/24.
Objective: To evaluate the effect of the Comprehensive Care for Joint Replacement (CJR) policy on the 90-day trajectory of post-acute care after a total hip arthroplasty (THA).
Design: Multivariable difference-in-difference models applied to Medicare beneficiaries undergoing a THA prior to (2014-2015) and post-CJR implementation (2017) in areas subjected to or exempt from the policy.
Setting: Hospitals in standard metropolitan statistical areas.
Objectives: To report the reduction in new neovascular age-related macular degeneration (nAMD) referrals during the COVID-19 pandemic and estimate the impact of delayed treatment on visual outcomes at 1 year.
Design: Retrospective clinical audit and simulation model.
Setting: Multiple UK National Health Service (NHS) ophthalmology centres.
Purpose: Management of neovascular age-related macular degeneration (nAMD) has evolved over the last decade with several treatment regimens and medications. This study describes the treatment patterns and visual outcomes over 10 years in a large cohort of patients.
Design: Retrospective analysis of electronic health records from 27 National Health Service secondary care healthcare providers in the UK.
Purpose: We sought to develop and validate a deep learning model for segmentation of 13 features associated with neovascular and atrophic age-related macular degeneration (AMD).
Design: Development and validation of a deep-learning model for feature segmentation.
Methods: Data for model development were obtained from 307 optical coherence tomography volumes.
One-in-four ophthalmology trials are single-armed, which poses challenges to their interpretation. We demonstrate how real-world cohorts used as external/synthetic control arms can contextualize such trials. We herein emulated a target trial on the intention-to-treat efficacy of off-label bevacizumab (q6w) pro re nata relative to fixed-interval aflibercept (q8w) for improving week 54 visual acuity of eyes affected by neovascular age-related macular degeneration.
View Article and Find Full Text PDFBackground/aims: The SARS-CoV-2 pandemic has imposed barriers to retinal care delivery worldwide. In this context, retinal services are exploring novel ways to ensure access to healthcare.
Methods: We conducted a worldwide survey among retinal specialists between March 31, 2020 and April 12, 2020.
Purpose: To report the visual acuity measures from the macular telangiectasia type 2 (MacTel) registry and to investigate and describe phenotypic findings in eyes with substantial vision loss resulting from MacTel.
Design: Cross-sectional multicenter study.
Participants: Participants in the MacTel Natural History Observation Registration Study.
Purpose: To evaluate the efficacy of a new laser imaging device that projects images onto functioning macular areas, to improve visual acuity (VA) in low-vision patients with macular diseases.
Methods: An interventional case series of consecutive patients with low vision in their right eyes (RE). RE VA was measured by showing the patients digits of various standard sizes and measuring their best-corrected VA (BCVA).
Purpose: To evaluate the utility of widefield optical coherence tomography angiography (WF-OCTA) compared with clinical examination in grading diabetic retinopathy in patients diagnosed clinically with proliferative diabetic retinopathy (PDR) or severe non-proliferative diabetic retinopathy (NPDR).
Design: This retrospective observational case series included patients diagnosed clinically with PDR or severe NPDR. Patients underwent standard clinical examination and WF-OCTA imaging (PLEX Elite 9000, Carl Zeiss Meditec AG) using 12×12 montage scans between August 2018 and January 2019.
Objective Evaluation of Proliferative Diabetic Retinopathy Using OCT.
Ophthalmol Retina
February 2020
Purpose: To present the routine use of OCT and OCT angiography (OCTA) for the objective diagnosis and monitoring of proliferative diabetic retinopathy (PDR).
Design: Retrospective, observational case series.
Participants: Patients with diabetic retinopathy imaged using a standardized PDR protocol.
Background And Objective: Retinovascular anomalies in the fellow eyes of patients with Coats' disease have been described, but the clinical significance is unknown, as well as whether these lesions progress over time.
Patients And Methods: This is an international, multicenter, retrospective, observational cohort study of fellow-eye abnormalities on widefield fluorescein angiography in patients with Coats' disease.
Results: Three hundred fifty eyes of 175 patients with Coats' disease were analyzed.
Purpose: To develop a diagnostic algorithm in patients with pathologic myopia who present with typical symptoms or signs of myopic choroidal neovascularisation (mCNV).
Methods: Retrospective study. Patients with high myopia and suspected mCNV underwent fluorescein angiography (FFA), structural spectral-domain optical coherence tomography (SD-OCT) and optical coherence tomography angiography (OCTA).
Purpose: To determine vascular change at the macula in both eyes in unilateral pediatric Coats disease using optical coherence tomography angiography.
Methods: Retrospective case-series. Thirteen eyes of pediatric patients with a diagnosis of unilateral Coats disease of various stages were compared with 13 fellow eyes.
Localization of Paracentral Acute Middle Maculopathy Using Optical Coherence Tomography Angiography.
Ophthalmic Surg Lasers Imaging Retina
August 2018
Paracentral acute middle maculopathy (PAMM) refers to band-like hyperreflective lesions seen on spectral-domain optical coherence tomography, mostly confined to the inner nuclear layer. It has been previously demonstrated to involve the deep capillary plexus (DCP) using optical coherence tomography angiography (OCTA). A 29-year-old female presented with PAMM and was investigated using a new OCTA system that shows not just the superficial capillary plexus and DCP, but also the four vascular plexuses as previously demonstrated in histology.
View Article and Find Full Text PDFNormative Data on Foveal Avascular Zone Dimensions in Four Macular Vascular Layers.
Ophthalmic Surg Lasers Imaging Retina
August 2018
Background And Objectives: To provide normative data on the size of the foveal avascular zone (FAZ) in the four histological retinal vascular layers as measured using optical coherence tomography angiography (OCTA) and evaluate interobserver variability.
Patients And Methods: Two graders measured the FAZ area in each layer (nerve fiber layer [NFL], ganglion cell layer [GCL], inner plexiform layer to inner nuclear layer [INL], and INL to outer plexiform layer), as well as the superficial and deep capillary plexuses.
Results: Forty-seven eyes of 25 subjects were included.
Purpose: To determine the evolution of fundus autofluorescence (FAF) patterns in chronic central serous chorioretinopathy (CSCR) over time.
Methods: We retrospectively studied the changes in FAF patterns over time in 157 eyes of 112 patients with chronic CSCR using the Heidelberg Retina Angiography with a 488-nm excitation light and a 500-nm cutoff barrier filter.
Results: The mean duration of follow-up was 37.
The relation of somatotypes and stress response to central serous chorioretinopathy.
Graefes Arch Clin Exp Ophthalmol
December 2017
Purpose: To investigate a possible relationship between central serous chorioretinopathy (CSC) and specific body types and compositions (somatotypes), and to examine the cortisol stress response among CSC patients of different somatotypes in comparison with healthy subjects.
Methods: Prospective case-control study. A group of 28 patients with a previous or current diagnosis of CSC was compared with a group of 26 healthy subjects.
Purpose: To evaluate the efficacy and safety of eplerenone for chronic nonresolving central serous chorioretinopathy (CSC).
Methods: Prospective, double-blind, randomized placebo-controlled study. Nineteen eyes of 17 patients with persistent subretinal fluid (SRF) due to CSC were enrolled and randomized to receive eplerenone 50 mg/day or placebo for 3 months, followed by a 3-month follow-up.